Best Practice & Research Clinical Rheumatology
Volume 20, Issue 1 , Pages 131-144 , February 2006

Do intra-articular therapies work and who will benefit most?

References 

  1. American College of Rheumatology Subcommittee on osteoarthritis guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum. 2000;43:1905–1915
  2. Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Annals of the Rheumatic Diseases. 2003;62:1145–1155
  3. Hochberg MC, Perlmutter DL, Hudson JI, Altman RD. Preferences in the management of osteoarthritis of the hip and knee: results of a survey of community based rheumatologists in the United States. Arthritis Care Research. 1996;9:170–176
  4. Creamer P. Intra-articular corticosteroid treatment in osteoarthritis. Current Opinion in Rheumatology. 1999;11:417–421
  5. Ayral X. Injections in the treatment of osteoarthritis. Best Practice and Research Clinical Rheumatology. 2001;15:609–626
  6. Miller JH, White J, Norton TH. The value of intra-articular injections in osteoarthritis of the knee. The Journal of Bone and Joint Surgery. 1958;4013:636–643
  7. Wright V, Chandler GN, Morison RA, Hartfall SJ. Intra-articular therapy in osteoarthritis. Comparison of hydrocortisone acetate and hydrocortisone tertiary-butylacetate. Annals of the Rheumatic Diseases. 1960;19:257–261
  8. Cederlof S, Jonson G. Intra-articular prednisolone injection for osteoarthritis of the knee. Acta Chirurgia Scandinavica. 1966;132:532–536
  9. Friedman DM, Moore ME. The efficacy of intra-articular steroids in osteoarthritis: A double blind study. The Journal of Rheumatology. 1980;7:850–856
  10. Dieppe PA, Sathapayavongs B, Jones HE, et al. Intra-articular steroids in osteoarthritis. Rheumatology and Rehabilitation. 1980;19:212–217
  11. Valtonen E. Clinical comparison of triamcinolone hexacetonide and bethamethasone in the treatment of osteoarthritis of the knee joint. Scandinavian Journal of Rheumatology. 1981;41:3–7
  12. Sambrook PN, Champion GD, Browne CD, et al. Corticosteroid injection for osteoarthritis of the knee: Peripatellar compared to intra-articular route. Clinical Rheumatology. 1989;7:609–613
  13. Gaffney K, Ledingham J, Perry JD. Intra-articular triamcinolone hexacetonide in knee osteoarthritis: Factors influencing the clinical response. Annals of the Rheumatic Diseases. 1995;54:379–381
  14. Jones A, Doherty M. Intra-articular corticosteroids are effective in osteoarthritis but there are no clinical predictors of response. Annals of the Rheumatic Diseases. 1996;55:829–832
  15. Ravaud P, Moulinier L, Giraudeau B, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: Results of a multicenter, randomized, controlled trial. Arthritis and Rheumatism. 1999;42:475–482
  16. Raynauld JP, Buckland-Wright C, Ward R, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial. Arthritis and Rheumatism. 2003;48:370–377
  17. Pyne D, Ioannou Y, Mootoo R, Bhanji A. Intra-articular steroids in knee osteoarthritis: A comparative study of triamcinolone hexacetonide and methylprednisolone acetate. Clinical Rheumatology. 2004;23:116–120[Epub 2004 Feb 24]
  18. Kirwan JR, Rankin E. Intra-articular therapy in osteoarthritis. Baillieres Clinical Rheumatology. 1997;11:769–794
  19. Gossec L, Dougados M. Intra-articular treatments in osteoarthritis: From the symptomatic to the structure modifying. Annals of the Rheumatic Diseases. 2004;63:478–482
  20. Towheed TE, Hochberg MC. A systematic review of randomized, controlled trials of pharmacological therapy in osteoarthritis of the knee. Seminars in Arthritis and Rheumatism. 1997;26:755–770
  21. Waseem M, Sadiq S, Gambhir AK, et al. Safety and efficacy of intra-articular injection of the hip. Hip International. 2002;12:378–382
  22. Plant MJ, Borg AA, Dziedzik K, et al. Radiographic patterns and response to corticosteroid hip injection. Annals of the Rheumatic Diseases. 1997;56:476–480
  23. Flanagan J, Casale FF, Thomas TL, Desai KB. Intra-articular injection for pain relief in patients awaiting hip replacement. Annals of the Royal College of Surgeons of England. 1988;70:156–157
  24. Kullenberg B, Runesson R, Tuvhag R, et al. Intraarticular corticosteroid injection: Pain relief in osteoarthritis of the hip?. The Journal of Rheumatology. 2004;31:2265–2268
  25. Qvistgaard E, Christensen R, Torp-Pedersen S, Bliddal H. Intra-articular treatment of hip osteoarthritis: A randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Annals of the Rheumatic Diseases. 2005;64(supplement 3):66;[abstract OP0032]
  26. Zhang W, Doherty M, Arden N, et al. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Annals of the Rheumatic Diseases. 2005;64:669–681
  27. Meenagh GK, Patton J, Kynes C, Wright GD. A randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis. Annals of the Rheumatic Diseases. 2004;63:1260–1263
  28. Elliott AL, Kraus VB, Luta G, et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 2005;52:105–111
  29. Agerup B, Berg P, Akermark C. Non-animal stabilized hyaluronic acid: A new formulation for the treatment of osteoarthritis. BioDrugs. 2005;19(1):23–30
  30. Brandt KD, Smith GN, Simon LS. Intraarticular injection of hyaluronan as treatment for knee osteoarthritis. What is the evidence?. Arthritis and Rheumatism. 2000;43:1192–1203
  31. Maheu E, Ayral X, Dougados M. A hyaluronan preparation (500–730 kDa) in the treatment of osteoarthritis: A review of clinical trials with hyalgan. International Journal of Clinical Practice. 2002;56:804–813
  32. Aggarwal A, Sempowski IP. Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature. Canadian Family Physician. 2004;50:249–256
  33. Wang CT, Lin J, Chang CJ, et al. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. The Journal of Bone and Joint Surgery American Volume. 2004;86-A(3):538–545Mar
  34. Lo GH, LaValley M, McAlindon T, Felson DT. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: A meta-analysis. The Journal of the American Medical Association. 2003;290:3115–3121
  35. Cohen J. 2nd edn. Statistical Power Analysis for the Behavioural Sciences. xxi. Hillsdale, NJ: L Erlbaum associates; 1998;p. 567
  36. Felson DT. The verdict favors nonsteroidal antiinflammatory drugs for treatment of osteoarthritis and a plea for more evidence on other treatments. Arthritis and Rheumatism. 2001;44:1477–1480
  37. Liang MH, Larson MG, Cullen KE, Schwartz JA. Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research. Arthritis and Rheumatism. 1985;28:542–547
  38. Pham T, Le Henanff A, Ravaud P, et al. Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis. Annals of the Rheumatic Diseases. 2004;63:1611–1617
  39. Altman RD, Akermark C, Beaulieu AD, Schnitzer T. Durolane international study group. Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee. Osteoarthritis and Cartilage. 2004;12:642–649
  40. Day R, Brooks P, Conaghan PG, et al. A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. The Journal of Rheumatology. 2004;31:775–782
  41. Bellamy N, Campbell J, Gee T, et al. Hylan G-F 20 for knee osteoarthritis (OA): a cochrane review. Arthritis and Rheumatism. 2003;48(supplement):S697;[abstract]
  42. Bellamy N, Campbell J, Gee T, et al. Intra-articular treatment of osteoarthritis of the knee. Corticosteroids versus hyaluronan/hylan: Cochrane review 2005. Annals of the Rheumatic Diseases. 2005;64(supplement 3):494;[SAT0270]
  43. Bellamy N, Campbell J, Gee T, et al. Hylan G-F 20 (SYNVISC) versus placebo: Cochrane review 2005. Annals of the Rheumatic Diseases. 2005;64(supplement 3):492;[SAT0263]
  44. Petrella RJ. Hyaluronic acid for the treatment of knee osteoarthritis: Long-term outcomes from a naturalistic primary care experience. American Journal of Physical Medicine and Rehabilitation. 2005;84(4):278–283
  45. Wobig M, Bach G, Beks P, et al. The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee: A comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan. Clinical Therapeutics. 1999;21(9):1549–1562
  46. Scale D, Wobig M, Wolpert W. Viscosupplementation of osteoarthritic knees with hylan: A treatment schedule study. Current Therapeutic Research. 1994;55:220–232
  47. Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: A 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clinical Therapeutics. 1998;20:410–423
  48. Karlsson J, Sjogren LS, Lohmander LS. Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis. A controlled, randomized, double-blind, parallel-design multicentre study. Rheumatology (Oxford). 2002;41(11):1240–1248
  49. Caborn D, Rush J, Lanzer W, et al. Synvisc 901 Study Group. A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee. The Journal of Rheumatology. 2004;31(2):333–343
  50. Tasciotaoglu F, Oner C. Efficacy of intra-articular sodium hyaluronate in the treatment of knee osteoarthritis. Clinical Rheumatology. 2003;22(2):112–117
  51. Leopold SS, Redd BB, Warme WJ, et al. Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee. A prospective, randomized trial. The Journal of Bone and Joint Surgery American Volume. 2003;85-A(7):1197–1203
  52. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (hyalgan) in the treatment of patients with osteoarthritis of the knee: A randomized clinical trial. Hyalgan study group. The Journal of Rheumatology. 1998;25:2203–2212
  53. Adams ME, Atkinson MH, Lussier AJ, et al. The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis and Cartilage. 1995;3:213–225
  54. Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled clinical trial. Archives of Internal Medicine. 2002;162:292–298
  55. Brocq O, Tran G, Breuil V, et al. Hip osteoarthritis: Short-term efficacy and safety of viscosupplementation by hylan G-F 20. An open-label study in 22 patients. Joint Bone Spine. 2002;69:388–391
  56. Migliore A, Martin LS, Alimonti A, et al. Efficacy and safety of viscosupplementation by ultrasound-guided intra-articular injection in osteoarthritis of the hip. Osteoarthritis and Cartilage. 2003;11:305–306
  57. Migliore A, Tormenta S, Martin LS. Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis. Clinical Rheumatology. 2004;December 9:[Epub ahead of print]
  58. Vad VB, Sakalkale D, Sculco TP, Wickiewicz TL. Role of hylan G-F 20 in treatment of osteoarthritis of the hip joint. Archives of Physical Medicine and Rehabilitation. 2003;84:1224–1226
  59. Conrozier T, Bertin P, Mathieu P, et al. Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: An open-label, multicentre, pilot study. Clinical and Experimental Rheumatology. 2003;21:605–610
  60. Migliore A, Tormenta S, Massafra U, et al. Ultrasound guided intra-articular administration of hylan G-F 20 in 223 patients suffering from symptomatic hip osteoarthritis. Annals of the Rheumatic Diseases. 2005;64(supplement 3):487;[abstract SAT0247]
  61. Tikiz C, Unlu Z, Sener A, et al. Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis. Clinical Rheumatology. 2005;January 13:[Epub ahead of print]
  62. Leardini G, Perbellini A, Franceschini M, Mattara L. Intra-articular injections of hyaluronic acid in the treatment of painful shoulder. Clinical Therapeutics. 1988;10:521–526
  63. Petrella RJ. Hyaluronic acid in treatment of osteoarthritis of the shoulder. 64(supplement 3): 481 [abstract SAT0229].
  64. Blyth T, Stirling A, Coote J, et al. Injection of the rheumatoid knee: Does intra-articular methotrexate or rifampicin add to the benefits of triamcinolone hexacetonide?. British Journal of Rheumatology. 1998;37:770–772
  65. Snibbe JC, Gambardella RA. Treatment options for osteoarthritis. Orthopedics. 2005;28(supplement 2):s215–s220
  66. Brown DJ, Wood EV, Hannah HM, et al. Prospective comparison of sodium hyaluronate and hylan G-F 20 in a clinical practice. Arthritis and Rheumatism. 2004;50:1697–1698
  67. Puttick MP, Wade JP, Chalmers A, et al. Acute local reactions after intraarticular hylan for osteoarthritis of the knee. The Journal of Rheumatology. 1995;22:1311–1314
  68. Lussier A, Cividino AA, McFarlane CA, et al. Viscosupplementation with hylan for the treatment of osteoarthritis: Findings from clinical practice in Canada. The Journal of Rheumatology. 1996;23:1579–1585
  69. Bucher W, Otto T, Hamburger MI. Differentiation of hyaluronate products by qualitative differences in their immunogenicity in rabbits: Possible mechanism for product-specific severe adverse reactions?. Arthritis and Rheumatism. 2002;46:2543–2544
  70. Punzi L, Pianon M, Piero SG, Todesco S. Pseudogout and intraarticular hyaluronate injections: Comment on the article by Disla et al. Arthritis and Rheumatism. 2000;43:1660–1661
  71. Kolarz G, Kotz R, Hochmayer I. Long-term benefits and repeated treatment cycles of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee. Seminars in Arthritis and Rheumatism. 2003;32:310–319
  72. Smith G, Myers SL, Brandt KD, et al. Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection. The Journal of Rheumatology. 2005;32:325–334
  73. Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: Mechanisms of action. Arthritis Research and Therapy. 2003;5:54–67
  74. Sezgin M, Demirel AC, Karaca C, et al. Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?. Rheumatology International. 2005;25:264–269
  75. Gomis A, Pawlak M, Balazs EA, et al. Effects of different molecular weight elastoviscous hyaluronan solutions on articular nociceptive afferents. Arthritis and Rheumatism. 2004;50:314–326
  76. Listrat V, Ayral X, Patarnello F, et al. Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee. Osteoarthritis and Cartilage. 1997;5:153–160
  77. Jubb RW, Piva S, Beinat L, et al. A one-year, randomised, placebo (saline) controlled clinical trial of 500–730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee. International Journal of Clinical Practice. 2003;57:467–474
  78. Ozturk C, Atamaz F, Hepguler S, et al. The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis: 1-year, single-blind, randomized study. Rheumatology International. 2005;February 10:[Epub ahead of print]
  79. Jones A, Regan M, Ledingham J, et al. Importance of placement of intra-articular steroid injections. British Medical Journal. 1993;307:1329–1330
  80. Brandt KD, Block JA, Michalski JP, et al. Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. ORTHOVISC study group. Clinical Orthopaedics. 2001;385:130–143
  81. Conrozier T, Mathieu P, Schott AM, et al. Factors predicting long-term efficacy of Hylan GF-20 viscosupplementation in knee osteoarthritis. Joint Bone Spine. 2003;70(2):128–133
  82. Toh EM, Prasad PS, Teanby D. Correlating the efficacy of knee viscosupplementation with osteoarthritic changes on roentgenological examination. Knee. 2002;9:321–330
  83. Torrance GW, Raynauld JP, Walker V, et al. A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with knee osteoarthritis (part 2 of 2): economic results. Osteoarthritis Cartilage. 2002;10:518–527
  84. Kahan A, Lleu PL, Salin L. Prospective randomized study comparing the medicoeconomic benefits of Hylan GF-20 vs. conventional treatment in knee osteoarthritis. Joint Bone Spine. 2003;70:276–281
  85. Yen ZS, Lai MS, Wang CT, et al. Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan. The Journal of Rheumatology. 2004;31:1797–1803

PII: S1521-6942(05)00105-1

doi: 10.1016/j.berh.2005.09.005

Best Practice & Research Clinical Rheumatology
Volume 20, Issue 1 , Pages 131-144 , February 2006