Best Practice & Research Clinical Rheumatology
Volume 20, Issue 3 , Pages 593-599, June 2006

Genetics of spondyloarthritis

  • Maxime Breban, MD, PhD (Professor of Rheumatology)

      Affiliations

    • Corresponding Author InformationAddress: Institut Cochin, INSERM U567/CNRS UMR8104/IFR116, Hôpital Cochin, 27 rue du Fg saint-Jacques, 75014 Paris, France. Tel.: +33 1490 94555; fax: +33 1490 95865.

Institut Cochin, INSERM U567/CNRS UMR8104/IFR116, Hôpital Cochin, Paris, France

Service de Rhumatologie, Hôpital Ambroise Paré, Boulogne, France

This chapter reviews evidence from family and twin studies supporting the strong genetic predisposition of the spondyloarthritides (SpA), which is only partially attributable to the major histocompatibility locus. The current concept of SpA heterogeneity has been challenged by family studies which showed that all articular and extra-articular manifestations were linked together, and most likely to the same genetic factors.

Key words: genetic, spondyloarthritis, ankylosing spondylitis, family study, psoriatic arthritis

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PII: S1521-6942(06)00032-5

doi:10.1016/j.berh.2006.03.002

Best Practice & Research Clinical Rheumatology
Volume 20, Issue 3 , Pages 593-599, June 2006

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