Best Practice & Research Clinical Rheumatology
Volume 21, Issue 3 , Pages 581-596 , June 2007

Future perspectives: pathogenesis of chronic muscle pain

  • Roland Staud, MD (Professor of Medicine, Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, Gainesville, Florida, USA)

      Affiliations

    • Corresponding Author InformationTel.: +1 352 273 5345; Fax: +1 352 392 8483.

References 

  1. Rachlin ES. Myofascial Pain and Fibromyalgia. In:  Rachlin ES editors. History and Physical examination for regional myofascial pain syndromes. St. Louis: Mosby; 1994;p. 159–172
  2. Simons DG, Travell JG, Simons LS, Cummings BD. Myofascial Pain and Dysfunction: The Trigger Point Manual. Upper Half of the Body. New York: Lippincott, Williams & Wilkins; 1999;
  3. Long SP, Kephart W. Myofascial Pain Syndrome. In:  Ashburn MA,  Rice LJ editor. The Management of Pain. Philadelphia: Churchill Livingstone; 1998;p. 299–321
  4. Gerwin RD. Myofascial pain syndromes in the upper extremity. Journal of Hand Therapy. 1997;10:130–136
  5. Han SC, Harrison P. Myofascial pain syndrome and trigger-point management. Regional Anesthesia. 1997;22:89–101
  6. Chu J. Twitch response in myofascial trigger points. Journal of Musculoskeletal Pain. 1998;6(4):99–116
  7. Skootsky SA, Jaeger B, Oye RK. Prevalence of myofascial pain in general internal medicine practice. The Western Journal of Medicine. 1989;151:157–160
  8. Gerwin RD. Classification, epidemiology, and natural history of myofascial pain syndrome. Current Pain and Headache Reports. 2001;5:412–420
  9. Simons DG, Mense S. Understanding and measurement of muscle tone as related to clinical muscle pain. Pain. 1998;75:1–17
  10. Shah JP, Phillips TM, Danoff JV, Gerber LH. An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. Journal of Applied Physiology. 2005;99:1977–1984
  11. Borg-Stein J, Simons DG. Myofascial pain. Archives of Physical Medicine and Rehabilitation. 2002;83:S40–S47
  12. Maekawa K, Clark GT, Kuboki T. Intramuscular hypoperfusion, adrenergic receptors, and chronic muscle pain. Journal of Pain. 2002;3:251–260
  13. Reinohl J, Hoheisel U, Unger T, Mense S. Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat. Neuroscience Letters. 2003;338:25–28
  14. Hubbard DR, Berkoff GM. Myofascial trigger points show spontaneous needle EMG activity. Spine. 1993;18:1803–1807
  15. Hong CZ, Yu J. Spontaneous electrical activity of rabbit trigger spot after transection of spinal cord and peripheral nerve. Journal of Musculoskeletal Pain. 1998;6:45–58
  16. Simons DG, Hong CZ, Simons LS. Endplate potentials are common to midfiber myofacial trigger points. American Journal of Physical Medicine and Rehabilitation. 2002;81:212–222
  17. Windisch A, Reitinger A, Traxler H, et al. Morphology and histochemistry of myogelosis. Clinical Anatomy. 1999;12:266–271
  18. Simons DG, Stolov WC. Microscopic features and transient contraction of palpable bands in canine muscle. American Journal of Physical Medicine. 1976;55:65–88
  19. Mense S, Simons DG. Muscle pain: Understanding its nature, diagnosis, and treatment. Philadelphia: Lippincott Williams and Wilkins; 2001;
  20. Mengshoel AM, Vollestad NK, Forre O. Pain and fatigue induced by exercise in fibromyalgia patients and sedentary healthy subjects. Clinical and Experimental Rheumatology. 1995;13:477–482
  21. Larsson R, Oberg PA, Larsson SE. Changes of trapezius muscle blood flow and electromyography in chronic neck pain due to trapezius myalgia. Pain. 1999;79:45–50
  22. Mense S. The pathogenesis of muscle pain. Current Pain and Headache Reports. 2003;7:419–425
  23. Sluka KA, Price MP, Breese NA, et al. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain. 2003;106:229–239
  24. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis and Rheumatism. 1990;33:160–172
  25. Sarzi-Puttini P, Atzeni F, Diana A, et al. Increased neural sympathetic activation in fibromyalgia syndrome. Annals of the New York Academy of Sciences. 2006;1069:109–117
  26. Crofford LJ. The relationship of fibromyalgia to neuropathic pain syndromes. The Journal of Rheumatology Supplement. 2005;75:41–45
  27. Gerwin RD. A review of myofascial pain and fibromyalgia - factors that promote their persistence. Acupuncture in Medicine. 2005;23:121–134
  28. Adler GK, Kinsley BT, Hurwitz S, et al. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. American Journal of Medicine. 1999;106:534–543
  29. Torpy DJ, Papanicolaou DA, Lotsikas AJ, et al. Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6-A pilot study in fibromyalgia. Arthritis and Rheumatism. 2000;43:872–880
  30. Russell IJ, Orr MD, Littman B, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis and Rheumatism. 1994;37:1593–1601
  31. Bradley LA, Alarcon GS, Sotolongo A, et al. Cerebrospinal fluid (CSF) levels of substance P (SP) are abnormal in patients with fibromyalgia (FM) regardless of traumatic or insidious pain onset. Arthritis and Rheumatism. 1998;41:S256
  32. Vaeroy H, Helle R, Forre O, et al. Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis. Pain. 1988;32:21–26
  33. Neeck G. Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. Scandinavian Journal of Rheumatology. 2000;29:8–12
  34. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. The Journal of the American Medical Association. 1992;267:1244–1252
  35. Czeisler CA, Klerman EB. Circadian and sleep-dependent regulation of hormone release in humans. Recent Progress in Hormone Research. 1999;54:97–130
  36. Sarlis NJ, Chowdrey HS, Stephanou A, Lightman SL. Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat. Endocrinology. 1992;130:1775–1779
  37. Crofford LJ, Young EA, Engleberg NC, et al. Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain, Behavior, and Immunity. 2004;18:314–325
  38. Adler GK, Geenen R. Hypothalamic-pituitary-adrenal and autonomic nervous system functioning in fibromyalgia. Rheumatic Diseases Clinics of North America. 2005;31:187–202xi
  39. Ulas U, Unlu E, Hamamcioglu K, et al. Dysautonomia in fibromyalgia syndrome: sympathetic skin responses and RR interval analysis. Rheumatology International. 2006;26:383–387
  40. Jeschonneck M, Grohmann G, Hein G, Sprott H. Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia. Rheumatology. 2000;39:917–921
  41. Cohen H, Neumann L, Shore M, et al. Autonomic dysfunction in patients with fibromyalgia: Application of power spectral analysis of heart rate variability. Seminars in Arthritis and Rheumatism. 2000;29:217–227
  42. Bou-Holaigah I, Calkins H, Flynn JA, et al. Provocation of hypotension and pain during upright tilt table testing in adults with fibromyalgia. Clinical and Experimental Rheumatology. 1997;15:239–246
  43. Furlan R, Colombo S, Perego F, et al. Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia. Journal of Rheumatology. 2005;32:1787–1793
  44. Vaeroy H, Qiao ZG, Morkrid L, Forre O. Altered sympathetic nervous system response in patients with fibromyalgia (fibrositis syndrome). Journal of Rheumatology. 1989;16:1460–1465
  45. Qiao ZG, Vaeroy H, Morkrid L. Electrodermal and microcirculatory activity in patients with fibromyalgia during baseline, acoustic stimulation and cold pressor tests. Journal of Rheumatology. 1991;18:1383–1389
  46. Dinerman H, Goldenberg DL, Felson DT. A prospective evaluation of 118 patients with the fibromyalgia syndrome: prevalence of Raynaud's phenomenon, sicca symptoms, ANA, low complement, and Ig deposition at the dermal-epidermal junction. Journal of Rheumatology. 1986;13:368–373
  47. Bennett RM, Clark SR, Campbell SM, et al. Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet alpha 2-adrenergic receptors. Arthritis and Rheumatism. 1991;34:264–269
  48. Grassi W, De AR, Lapadula G, et al. Clinical diagnosis found in patients with Raynaud's phenomenon: a multicentre study. Rheumatology International. 1998;18:17–20
  49. Coffman JD, Cohen AS. Total and capillary fingertip blood flow in Raynaud's phenomenon. New England Journal of Medicine. 1971;285:259–263
  50. Jamieson GG, Ludbrook J, Wilson A. Cold hypersenstivity in Raynaud's phenomenon. Circulation. 1971;44:254–264
  51. Lapossy E, Gasser P, Hrycaj P, et al. Cold-induced vasospasm in patients with fibromyalgia and chronic low back pain in comparison to healthy subjects. Clinical Rheumatology. 1994;13:442–445
  52. Price DD, Bennett GJ, Rafii A. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block. Pain. 1989;36:273–288
  53. Berglund B, Harju EL, Kosek E, Lindblom U. Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia. Pain. 2002;96:177–187
  54. Davis MC, Zautra AJ, Reich JW. Vulnerability to stress among women in chronic pain from fibromyalgia and osteoarthritis. Annals of Behavioral Medicine. 2001;23:215–226
  55. Giovengo SL, Russell IJ, Larson AA. Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia. Journal of Rheumatology. 1999;26:1564–1569
  56. Lewin GR, Mendell LM. Nerve growth factor and nociception. Trends in Neuroscience. 1993;16:353–359
  57. Petty BG, Cornblath DR, Adornato BT, et al. The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Annals of Neurology. 1994;36:244–246
  58. Fu KY, Light AR, Maixner W. Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw. Journal of Pain. 2001;2:2–11
  59. Wallace DJ, Linker-Israeli M, Hallegua D, et al. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology. 2001;40:743–749
  60. Salemi S, Rethage J, Wollina U, et al. Detection of interleukin 1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. Journal of Rheumatology. 2003;30:146–150
  61. Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH. Interleukin-8 as a mediator of sympathetic pain. British Journal of Pharmacology. 1991;104:765–767
  62. Henriksson KG. Is fibromyalgia a distinct clinical entity? Pain mechanisms in fibromyalgia syndrome. A myologist's view. Best Practice and Research. Clinical Rheumatology. 1999;13:455–461
  63. Henriksson KG. Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms. Journal of Rehabilitation Medicine. 2003;35:89–94
  64. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain. 1993;54:241–289
  65. Mense S, Schmidt RF. Muscle pain: which receptors are responsible for the transmission of noxious stimuli?. In:  Rose FC editors. Physiological aspects of clinical neurology. Oxford: Blackwell.Scientific.Publications; 1976;p. 265–278
  66. Mense S. Considerations concerning the neurobiological basis of muscle pain. Canadian Journal of Physiology and Pharmacology. 1991;69:610–616
  67. Lautenschlager J, Bruckle W, Schnorrenberger CC, Muller W. Measuring pressure pain of tendons and muscles in healthy probands and patients with generalized tendomyopathy (fibromyalgia syndrome). Zeitschrift für Rheumatologie. 1988;47:397–404
  68. Quimby LG, Block SR, Gratwick GM. Fibromyalgia: generalized pain intolerance and manifold symptom reporting. Journal of Rheumatology. 1988;15:1264–1270
  69. Tunks E, Crook J, Norman G, Kalaher S. Tender points in fibromyalgia. Pain. 1988;34:11–19
  70. Mikkelsson M, Latikka P, Kautiainen H, et al. Muscle and bone pressure pain threshold and pain tolerance in fibromyalgia patients and controls. Archives of Physical Medicine and Rehabilitation. 1992;73:814–818
  71. Kosek E, Ekholm J, Hansson P. Increased pressure pain sensibility in fibromyalgia patients is located deep to the skin but not restricted to muscle tissue. Pain. 1995;63:335–339
  72. Bendtsen L, Norregaard J, Jensen R, Olesen J. Evidence of qualitatively altered nociception in patients with fibromyalgia. Arthritis and Rheumatism. 1997;40:98–102
  73. Vierck CJ, Cannon RL, Fry G, et al. Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode. Journal of Neurophysiology. 1997;78:992–1002
  74. Hokfelt T, Zhang X, Su X, Wiesenfeld-Hallin Z. Central consequences of peripheral nerve damage. In:  McMahon S,  Koltzenburg M editor. Wall and Melzack's Textbook of Pain. London: Elsevier; 2005;p. 947–959
  75. Staud R, Vierck CJ, Cannon RL, et al. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain. 2001;91:165–175
  76. Staud R, Cannon RC, Mauderli AP, et al. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain. 2003;102:87–95
  77. Desmeules JA, Cedraschi C, Rapiti E, et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis and Rheumatism. 2003;48:1420–1429
  78. Sorensen J, Graven-Nielsen T, Henriksson KG, et al. Hyperexcitability in fibromyalgia. Journal of Rheumatology. 1998;25:152–155
  79. Kosek E, Ekholm J, Hansson P. Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. Pain. 1996;64:415–423
  80. Staud R, Vierck CJ, Robinson ME, Price DD. Overall fibromyalgia pain is predicted by ratings of local pain and pain related negative affect: possible role of peripheral tissues. Rheumatology. 2006;45:1409–1415
  81. Buskila D, Neumann L, Vaisberg G, et al. Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury. Arthritis and Rheumatism. 1997;40:446–452
  82. Plesh O, Wolfe F, Lane N. The relationship between fibromyalgia and temporomandibular disorders: prevalence and symptom severity. Journal of Rheumatology. 1996;23:1948–1952
  83. Bendtsen L, Jensen R, Olesen J. Decreased pain detection and tolerance thresholds in chronic tension-type headache. Archives of Neurology. 1996;53:373–376
  84. Lapossy E, Maleitzke R, Hrycaj P, et al. The frequency of transition of chronic low back pain to fibromyalgia. Scandinavian Journal of Rheumatology. 1995;24:29–33
  85. Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?. Gastroenterology. 2002;122:1140–1156
  86. Clauw DJ, Schmidt M, Radulovic D, et al. The relationship between fibromyalgia and interstitial cystitis. Journal of Psychiatric Research. 1997;31:125–131
  87. Walen HR, Oliver K, Groessl E, et al. Traumatic events, health outcomes, and health care use in patients with fibromyalgia. Journal of Musculoskeletal Pain. 2001;9:19–38
  88. Al Allaf AW, Dunbar KL, Hallum NS, et al. A case-control study examining the role of physical trauma in the onset of fibromyalgia syndrome. Rheumatology. 2002;41:450–453
  89. Buskila D, Neumann L. The development of widespread pain after injuries. Journal of Musculoskeletal Pain. 2002;10:261–267
  90. Wynne-Jones G, Jones GT, Wiles NJ, et al. Predicting new onset of widespread pain following a motor vehicle collision. Journal of Rheumatology. 2006;33:968–974
  91. Banic B, Petersen-Felix S, Andersen OK, et al. Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain. 2004;107:7–15
  92. Raphael KG, Marbach JJ, Klausner J. Myofascial face pain. Clinical characteristics of those with regional vs. widespread pain. Journal of the American Dental Association. 2000;131:161–171
  93. Hansson P, Ekblom A, Lindblom U, Marchettini P. Does acute intraoral pain alter cutaneous sensibility?. Journal of Neurology, Neurosurgery, and Psychiatry. 1988;51:1032–1036
  94. Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain. 1995;63:341–351
  95. Curatolo M, Petersen-Felix S, Arendt-Nielsen L, et al. Central hypersensitivity in chronic pain after whiplash injury. The Clinical Journal of Pain. 2001;17:306–315
  96. Okifuji A, Turk DC. Stress and psychophysiological dysregulation in patients with Fibromyalgia syndrome. Applied Psychophysiology and Biofeedback. 2002;27:129–141
  97. Bajaj P, Madsen H, et al. Antenatal women with or without pelvic pain can be characterized by generalized or segmental hypoalgesia in late pregnancy. Journal of Pain. 2002;3:451–460
  98. Ushida T, Willis WD. Changes in dorsal horn neuronal responses in an experimental wrist contracture model. Journal of Orthopaedic Science. 2001;6:46–52
  99. Hoheisel U, K Koch, Mense S. Functional reorganization in the rat dorsal horn during an experimental myositis. Pain. 1994;59:111–118
  100. Price DD, McHaffie JG, Larson MA. Spatial summation of heat-induced pain: influence of stimulus area and spatial separation of stimuli on perceived pain sensation intensity and unpleasantness. Journal of Neurophysiology. 1989;62:1270–1279
  101. Staud R, Vierck CJ, Robinson ME, Price DD. Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects. Pain. 2004;111:342–350
  102. Julien N, Goffaux P, Arsenault P, Marchand S. Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain. 2005;114:295–302
  103. Herren-Gerber R, Weiss S, Arendt-Nielsen L, et al. Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Medicine. 2004;5:366–376
  104. Verne GN, Robinson ME, Vase L, Price DD. Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients. Pain. 2003;105:223–230
  105. Sluka KA, Kalra A, Moore SA. Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. Muscle and Nerve. 2001;24:37–46
  106. Bengtsson A, Henriksson KG, Larsson J. Muscle biopsy in primary fibromyalgia. Light-microscopical and histochemical findings. Scandinavian Journal of Rheumatology. 1986;15:1–6
  107. Bartels EM, Danneskiold-Samsoe B. Histological abnormalities in muscle from patients with certain types of fibrositis. Lancet. 1986;1:755–757
  108. Kalyan-Raman UP, Kalyan-Raman K, Yunus MB, Masi AT. Muscle pathology in primary fibromyalgia syndrome: a light microscopic, histochemical and ultrastructural study. Journal of Rheumatology. 1984;11:808–813
  109. Pongratz DE, Spath M. Morphologic aspects of fibromyalgia. Zeitschrift für Rheumatologie. 1998;57:47–51
  110. Drewes AM, Andreasen A, Schroder HD, et al. Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. British Journal of Rheumatology. 1993;32:479–483
  111. Fassbender HG, Wegner K. Morphology and pathogenesis of soft-tissue rheumatism. Zeitschrift für Rheumatologie. 1973;32:355–374
  112. Yunus MB, Kalyan-Raman UP, Masi AT, Aldag JC. Electron microscopic studies of muscle biopsy in primary fibromyalgia syndrome: a controlled and blinded study. Journal of Rheumatology. 1989;16:97–101
  113. Lindman R, Hagberg M, Bengtson A, Henriksson KG. Changes in trapezius muscle structure in fibromyalgia and chronic trapezius myalgia. Journal of Musculoskeletal Pain. 1993;1:171–176
  114. Elvin A, Siosteen AK, Nilsson A, Kosek E. Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: A contrast media enhanced colour doppler study. European Journal of Pain. 2006;10:137–144
  115. Larsson SE, Alund M, Cai H, Oberg PA. Chronic pain after soft-tissue injury of the cervical spine: trapezius muscle blood flow and electromyography at static loads and fatigue. Pain. 1994;57:173–180
  116. Bennett RM, Clark SR, Goldberg L, et al. Aerobic fitness in patients with fibrositis. A controlled study of respiratory gas exchange and 133xenon clearance from exercising muscle. Arthritis and Rheumatism. 1989;32:454–460
  117. Lund N, Bengtsson A, Thorborg P. Muscle tissue oxygen pressure in primary fibromyalgia. Scandinavian Journal of Rheumatology. 1986;15:165–173
  118. Strobel ES, Krapf M, Suckfull M, et al. Tissue oxygen measurement and 31P magnetic resonance spectroscopy in patients with muscle tension and fibromyalgia. Rheumatology International. 1997;16:175–180
  119. Lindh M, Johansson G, Hedberg M, et al. Muscle fiber characteristics, capillaries and enzymes in patients with fibromyalgia and controls. Scandinavian Journal of Rheumatology. 1995;24:34–37
  120. Lindman R, Hagberg M, Bengtsson A, et al. Capillary structure and mitochondrial volume density in the trapezius muscle of chronic trapezius myalgia, fibromyalgia and healthy subjects. Journal of Musculoskeletal Pain. 1995;3:5–22
  121. Bengtsson A, Bengtsson M. Regional sympathetic blockade in primary fibromyalgia. Pain. 1988;33:161–167
  122. Mense S, Stahnke M. Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat. Journal of Physiology. 1983;342:383–397
  123. Vierck CJ, Staud R, Price DD, et al. The effect of maximal exercise on temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Journal of Pain. 2001;2:334–344
  124. Bengtsson A. The muscle in fibromyalgia. Rheumatology. 2002;41:721–724
  125. Granges G, Littlejohn GO. A comparative study of clinical signs in fibromyalgia/fibrositis syndrome, healthy and exercising subjects. Journal of Rheumatology. 1993;20:344–351
  126. Neumann L, Zeldets V, Bolotin A, Buskila D. Outcome of posttraumatic fibromyalgia: A 3-year follow-up of 78 cases of cervical spine injuries. Seminars in Arthritis and Rheumatism. 2003;32:320–325
  127. Bengtsson M, Bengtsson A, Jorfeldt L. Diagnostic epidural opioid blockade in primary fibromyalgia at rest and during exercise. Pain. 1989;39:171–180
  128. Gracely RH, Lynch SA, Bennett GJ. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain. 1992;51:175–194
  129. Sorensen J, Bengtsson A, Ahlner J, et al. Fibromyalgia–are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs. Journal of Rheumatology. 1997;24:1615–1621
  130. Graven-Nielsen T, Aspegren KS, Henriksson KG, et al. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain. 2000;85:483–491
  131. Granot M, Buskila D, Granovsky Y, et al. Simultaneous recording of late and ultra-late pain evoked potentials in fibromyalgia. Clinical Neurophysiology. 2001;112:1881–1887
  132. Lorenz J, Grasedyck K, Bromm B. Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroencephalography and Clinical Neurophysiology. 1996;100:165–168
  133. Lautenbacher S, Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. The Clinical Journal of Pain. 1997;13:189–196
  134. Yunus MB. Towards a model of pathophysiology of fibromyalgia: aberrant central pain mechanisms with peripheral modulation. Journal of Rheumatology. 1992;19:846–850
  135. Granges G, Littlejohn G. Pressure pain threshold in pain-free subjects, in patients with chronic regional pain syndromes, and in patients with fibromyalgia syndrome. Arthritis and Rheumatism. 1993;36:642–646
  136. Staud R, Price DD, Robinson ME, et al. Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls. Pain. 2004;110:689–696
  137. Arendt-Nielsen L, Graven-Nielsen T. Central sensitization in fibromyalgia and other musculoskeletal disorders. Current Pain and Headache Reports. 2003;7:355–361
  138. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis and Rheumatism. 2002;46:1333–1343
  139. Cook DB, Lange G, Ciccone DS, et al. Functional imaging of pain in patients with primary fibromyalgia. Journal of Rheumatology. 2004;31:364–378
  140. Kong J, White NS, Kwong KK, et al. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Human Brain Mapping. 2006;27:715–721

PII: S1521-6942(07)00027-7

doi: 10.1016/j.berh.2007.02.013

Best Practice & Research Clinical Rheumatology
Volume 21, Issue 3 , Pages 581-596 , June 2007