Best Practice & Research Clinical Rheumatology
Volume 21, Issue 3 , Pages 535-547 , June 2007

Genetics of chronic pain states

  • Dan Buskila, MD (Professor)

      Affiliations

    • Corresponding Author InformationTel.: +972-507883360; Fax: +972-86403201.

References 

  1. Neumann L, Buskila D. Epidemiology of fibromyalgia. Current Pain and Headache Reports. 2003;7:362–368
  2. Mogil JS. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proceedings of the National Academy of Sciences of the United States of America. 1999;96:7744–7751
  3. Moller AT, Kolvraa S, Jensen TS. Pain and genetics. Ugeskrift for laeger. 2006;168:1044–1047
  4. Kim H, Neubert JK, San Miguel A, et al. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain. 2004;109:488–496
  5. Fillingim RB, Kaplan L, Stand R, et al. The A118G single nucleotide polymorphism of the mu-opiod receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. Journal of Pain. 2005;6:159–167
  6. Lachman HM, Papolos DF, Saito T, et al. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6:243–250
  7. Zubieta JK, Heitzeg MM, Smith YR, et al. COMT val 158 met genotype affects mu-opioid neurotrasmiter responses to a pain stressor. Science. 2003;299:1240–1243
  8. Diatchenko L, Slade GD, nackley AG, et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Human Molecular Genetics. 2005;14:135–143
  9. Rakvag TT, Klepstad P, Baar C, et al. The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain. 2005;116:73–78
  10. Armero P, Muriel C, Santos J, et al. COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population. European Journal of Pain. 2005;9:229–232
  11. Indo Y, Tsuruta M, Hayashida Y, et al. Mutations in the TRKA/NGF receptor gene in patients with congenial insensitivity to pain with anhidrosis. Nature Genetics. 1996;13:485–488
  12. Orphoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episode ataxia type 2 are caused by mutation in the Ca2+ channel gene CACNL1A4. Cell. 1996;87:543–552
  13. Dadabhoy D, Clauw D. Therapy insight: Fibromyalgia a different type of pain needing a different type of treatment. Nature Clinical Practice. Rheumatology. 2006;2:364–372
  14. Buskila D, Neumann L, Press J. Genetic factors in neuromuscular pain. CNS Spectrums. 2005;10:281–284
  15. Buskila D, Neumann L. Genetics of fibromyalgia. Current Pain and Headache Reports. 2005;9:313–315
  16. Ablin JN, Buskila D. The genetics of fibromyalgia – closing Osler's backdoor. Israel Medical Assocation Journal. 2006;8:428–429
  17. Pellegrino MJ, Walonis GW, Sommer A. familial occurrence of primary fibromyalgia. Archives of Physical Medicine and Rehabilitation. 1989;70:61–63
  18. Stromorken H, Brosstad F. Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a ‘true’ disease. Scandinavian Journal of Rheumatology. 1992;21:207
  19. Yunus M, Masi AT, Calabro JJ, et al. Primary fibromyalgia (fibrosistis): clinical study of 50 patients with matched normal control. Seminars in Arthritis and Rheumatism. 1981;11:151–171
  20. Roizenblatt S, Tufik S, Goldenberg J, et al. Juvenile fibromyalgia: Clinical and polysomnographic aspects. Journal of Rheumatology. 1997;24:579–585
  21. Buskila D, Neumann L, Hazanov I, Carmi R. Familial aggregation in the fibromyalgia syndrome. Seminars in Arthritis and Rheumatism. 1996;26:605–611
  22. Buskila D, Neumann L. Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. Journal of Rheumatology. 1997;24:941–944
  23. Neumann L, Buskila D. Quality of life and physical functioning of relatives of fibromyalgia patients. Seminars in Arthritis and Rheumatism. 1997;26:834–839
  24. Arnold LM, Hudson JI, Hess EV, et al. Family study of fibromyalgia. Arthritis and Rheumatism. 2004;50:944–952
  25. Burda CD, Cox FR, Osborne P. Histocompatibility antigens in the fibrosistis (fibromyalgia) syndrome. Clinical and Experimental Rheumatology. 1986;4:355–358
  26. Yunus MB, Khan MA, Rawlings KK, et al. Genetic linkage analysis of multicase families with fibromyalia syndrome. Journal of Rheumatology. 1999;26:408–412
  27. Lowe JC, Cullum ME, Graf LH, Yellin J. Mutations in the C-erbA beta 1 gene: do they underlie underlie euthyroid fibromyalgia?. Medical Hypotheses. 1997;48:125–135
  28. Offenbaecher M, Bondy B, Jonge de Silvia, et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis and Rheumatism. 1999;42:2482–2488
  29. Bondy B, Spaeth M, Offenbaecher M, et al. The T102C polymorphism of the 5-HT2A receptor gene in fibromyalgia. Neurobiology of Disease. 1999;6:433–439
  30. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis and Rheumatism. 2002;46:845–847
  31. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–1531
  32. Frank B, Niesler B, Bondy B, et al. Mutational analysis of serotonin receptor genes: HTR 3A and HTR3B in fibromyalgia patients. Clinical Rheumatology. 2004;23:338–344
  33. Gursoy S. Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clinical Rheumatology. 2002;21:194–197
  34. Gursoy S, Erdal E, Herken H, et al. Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatology International. 2003;23:104–107
  35. Buskila D, Cohen H, Neumann L, Ebstein RP. An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Molecular Psychiatry. 2004;9:730–731
  36. Malt EA, Olafsson S, Aakvaag A, et al. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. Journal of Affective Disorders. 2003;75:77–82
  37. Clauw DJ, Crofford LJ. Chronic widespread pain and fibromyalgia: what we know, and what we need to know. Best Practice and Research. Clinical Rheumatology. 2003;17:685–701
  38. Barsky AJ, Borus JF. Functional somatic syndrome. Annals of Internal Medicine. 1999;130:910–921
  39. Hudson JI, Mangweth B, Pope HG, et al. Family study of affective spectrum disorder. Archives in General Psychiatry. 2003;60:170–177
  40. Sperber AD, Atzmon Y, Neumann L, et al. Fibromyalgia in irritable bowel syndrome: studies of prevalence and clinical implications. American Journal of Gastroenterology. 1999;94:3541–3546
  41. Cohen H, Neumann L, Haiman Y, et al. Prevalence of post traumatic stress disorder in fibromyalgia patients: overlapping syndromes or post traumatic fibromyalgia syndrome?. Seminars in Arthritis and Rheumatism. 2002;32:38–50
  42. Hudson JI, Arnold LM, Keck PE, et al. Family study of fibromyalgia and affective spectrum disorder. Biological Psychiatry. 2004;56:884–891
  43. Walsh CM, Zainal NZ, Middleton SJ, Paykel ES. A family history study of chronic fatigue syndrome. Psychiatric Genetics. 2001;11:123–128
  44. Buchwald D, Herreli R, Ashton S, et al. A twin study of chronic pain. Psychosomatic Medicine. 2001;63:936–943
  45. Kalantar JS, Locke GR, Zinsmeister AR, et al. Familial aggregation of irritable bowel syndrome: a prospective study. Gut. 2003;52:1703–1707
  46. Landy S, Ricek L, Lobo B. Central sensitization and cutaneous allodynia in migraine: implications for treatment. CNS Drugs. 2004;18:337–342
  47. Ifergane G, Buskila D, Simiseshvely N, et al. Prevalence of fibromyalgia syndrome in migraine patients. Cephalalgia. 2006;26:451–456
  48. Amir M, Kaplan Z, Neumann L, et al. Posttraumatic stress disorder, tendernrss and fibromyalgia. Journal of Psychosomatic Research. 1997;42:607–613
  49. Koenen KC, Lyons MJ, Goldenberg J, et al. A high risk twin study of combat related PTSD comorbidity. Twin Research. 2003;6:218–226
  50. Stein MB, Jang KL, Taylor S, et al. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder syndromes: a twin study. American Journal of Psychiatry. 2002;159:1675–1681
  51. Narita M, Nishigami N, Narita N, et al. Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochemical and Biophysical Research Communications. 2003;311:264–266
  52. Smith AK, White PD, Aslakson E, et al. Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue. Pharmacogenomics. 2006;7:387–394
  53. Goertzel BN, Pennachin C, de Souza Coelho L, et al. Combination of single nucleotide polymorphisms in neuroendocrine effector's and receptor genes predict chronic fatigue syndrome. Pharmacogenomics. 2006;7:475–483
  54. Kaiser J. Biomedicine. Genes and chronic fatigue: how strong is the evidence?. Science. 2006;312(5774):669–671
  55. Carlo-Stella N, Badulli C, De Silvestri A, et al. A first study of cytokine genetic polymorphisms in CFS: Positive association of TNF - 857 and IFNgamma 874 rare alleles. Clinical and Experimental Rheumatology. 2006;24:179–182
  56. Yeo A, Boyd P, Lumsden S, et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhea predominant irritable bowel syndrome in women. Gut. 2004;53:1452–1458
  57. Pata C, Erdal E, yazc K, et al. Association of the 1438 G/A and 102 T/C polymorphism of the 5-HT2A receptor gene in irritable bowel syndrome. Journal of Clinical Gastroenterology. 2004;38:561–566
  58. Kim HJ, Camilleri M, Carlson PJ, et al. Association of distinct alpha (2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic syndromes in functional gastrointestinal disorders. Gut. 2004;53:829–837
  59. Pata C, Erdal ME, Derici E, et al. Serotonin transporter gene polymorphism in irritable bowel syndrome. American Journal of Gastroenterology. 2002;97:1780–1784
  60. Mutlu N, Erdal ME, Herken H, et al. T102 polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction. Oral Disease. 2004;10:349–352
  61. Segman RH, Cooper-Kazaz R, Macciardi F, et al. Association between the dopamine transporter gene and posttraumatic stress disorder. Molecular Psychiatry. 2002;7:903–907
  62. Lawford BR, McD Young R, Noble EP, et al. D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder. European Neuropsychopharmacology. 2003;13:313–320
  63. Lee HJ, Lee MS, Kang RH, et al. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety. 2005;21:135–139
  64. Juhasz G, Zsombok T, Laszik A, et al. Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102 T/C polymorphism and migraine. Journal of Neurogenetics. 2003;17:231–240
  65. Borroni B, Brambilla C, Liberini P, et al. Functional serotonin 5-HTTLPR polymorphism is a risk factor for migraine with aura. The Journal of Headache and Pain. 2005;6:182–184
  66. Mochi M, Gevoli S, Cortelli P, et al. A genetic association study of migraine with dopamine receptor 4, dopamine transporter and dopamine-beta-hydroxylase genes. Neurological Science. 2003;23:301–305
  67. Ramasubbu R, Tobias R, Buchan AM, Bech-Hansen NT. Serotonin transporter gene promoter region polymorphism associated with poststroke major depression. The Journal of Neuropsychiatry and Clinical Neurosciences. 2006;18:96–99
  68. Whyte EM, Pollock BG, Wagner WR, et al. Influence of serotonin transporter linked promoter region polymorphism on platelet activation in geriatric depression. American Journal of Psychiatry. 2001;158:2074–2076
  69. Park JS, Zhang SY, Jo SH, et al. Common adrenergic receptor polymorphism as novel risk factors for vasospastic angina. American Heart Journal. 2006;151:864–869
  70. Turk DC, Okifuji A, Sinclair JD, Startz TW. Pain, disability, and physical functioning in subgroups of patients with fibromyalgia. Journal of Rheumatology. 1996;23:1255–1262
  71. Giesecke T, Williams DA, Harris RE, et al. Subgrouping of fibromyalgia patients on the basis of pressure pain thresholds and psychological factors. Arthritis and Rheumatism. 2003;48:2916–2922
  72. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis and Rheumatism. 1990;33:10–172

PII: S1521-6942(07)00029-0

doi: 10.1016/j.berh.2007.02.011

Best Practice & Research Clinical Rheumatology
Volume 21, Issue 3 , Pages 535-547 , June 2007

Article Tools