Best Practice & Research Clinical Rheumatology
Volume 21, Issue 6 , Pages 1025-1036, December 2007

Localized scleroderma and systemic sclerosis: Is there a connection?

  • Rajnish A. Gupta, MD, PhD (Fellow)
    • ,
  • David Fiorentino, MD, PhD (Assistant Professor)

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Dermatology, Stanford University Medical Center, 900 Blake Wilbur Drive, Stanford, CA 94305, USA. Tel.: +1 650 723 9913; Fax: +1 650 723 7796.

Department of Dermatology, Stanford University School of Medicine, California, USA

Excess fibrosis of the skin is a clinical hallmark of both localized scleroderma and systemic sclerosis. Localized scleroderma is generally thought to be a skin-limited disease whereas systemic sclerosis can have a wide range of internal organ involvement. Recent data suggest that a subset of patients with juvenile localized scleroderma can go on to develop systemic involvement of their disease. This raises the question of what the connection is, if any, between localized scleroderma and systemic sclerosis.

Key words: juvenile localized scleroderma, localized scleroderma, morphea, systemic sclerosis, tissue fibrosis

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PII: S1521-6942(07)00106-4

doi:10.1016/j.berh.2007.09.003

Best Practice & Research Clinical Rheumatology
Volume 21, Issue 6 , Pages 1025-1036, December 2007

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