Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations

The extracellular calcium (Ca²⁺_o)-sensing receptor (CaSR) enables the parathyroid glands and other CaSR-expressing cells involved in calcium homeostasis, such as the kidney and bone, to sense alterations in the level of Ca²⁺_o and to respond with changes in function that are directed at normalizing the blood calcium concentration. Several disorders of Ca²⁺_o sensing arise from inherited or acquired abnormalities that ‘reset’ the serum calcium concentration upwards or downwards. Heterozygous inactivating mutations of the CaSR produce a benign form of hypercalcaemia, termed ‘familial hypocalciuric hypercalcaemia’, while homozygous mutations produce a much more severe hypercalcaemic disorder resulting from marked hyperparathyroidism, called ‘neonatal severe hyperparathyroidism’. Activating mutations cause a hypocalcaemic syndrome of varying severity, termed ‘autosomal-dominant hypocalcaemia or hypoparathyroidism’ as well as Bartter's syndrome type V. Calcimimetic CaSR activators and calcilytic CaSR antagonists have also been developed with potential for use in the treatment of these disorders.

Key words: seven transmembrane receptor, mutations, polymorphisms, calcium-sensing receptor, calcium homeostasis, calcimimetic, calcilytic, familial hypocalciuric hypercalcaemia, autosomal-dominant hypoparathyroidism, acquired hypoparathyroidism, osteoporosis, hyperparathyroidism, Bartter's syndrome