Best Practice & Research Clinical Rheumatology
Volume 22, Issue 2 , Pages 209-220 , April 2008

Joint homeostasis, restoration, and remodeling in osteoarthritis

  • Rik J.U. Lories, MD, PhD (Associate Professor)

      Affiliations

    • Corresponding Author InformationDepartment of Rheumatology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 342542; Fax: +32 16 342543.

References 

  1. Luyten FP, Lories RJ, Verschueren P, et al. Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Practice & Research. Clinical Rheumatology. 2006;20:829–848
  2. De Vlam K, Lories RJ, Luyten FP. Mechanisms of Pathologic New Bone Formation. Current Rheumatology Reports. 2006;8:332–337
  3. Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006;332:639–642
  4. Goldring MB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Practice & Research. Clinical Rheumatology. 2006;20:1003–1025
  5. Brandt KD, Radin EL, Dieppe PA, et al. Yet more evidence that osteoarthritis is not a cartilage disease. Annals of the Rheumatic Diseases. 2006;65:1261–1264
  6. Lajeunesse D, Reboul P. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Current Opinion in Rheumatology. 2003;15:628–633
  7. Lories RJ, Luyten FP. Bone Morphogenetic Protein signaling in joint homeostasis and disease. Cytokine & Growth Factor Reviews. 2005;16:287–298
  8. Li MO, Wan YY, Sanjabi S, et al. Transforming growth factor-beta regulation of immune responses. Annual Review of Immunology. 2006;24:99–146
  9. Verrecchia F, Mauviel A, Farge D. Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmunity Reviews. 2006;5:563–569
  10. Urist MR. Bone: formation by autoinduction. Science. 1965;150:893–899
  11. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988;242:1528–1534
  12. Mishina Y. Function of bone morphogenetic protein signaling during mouse development. Frontiers in Bioscience. 2003;8:D855–D869
  13. Chang SC, Hoang B, Thomas JT, et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. The Journal of Biological Chemistry. 1994;269:28227–28234
  14. Storm EE, Huynh TV, Copeland NG, et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature. 1994;368:639–643
  15. Thomas JT, Lin K, Nandedkar M, et al. A human chondrodysplasia due to a mutation in a TGF-beta superfamily member. Nature Genetics. 1996;12:315–317
  16. Thomas JT, Kilpatrick MW, Lin K, et al. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nature Genetics. 1997;17:58–64
  17. Polinkovsky A, Robin NH, Thomas JT, et al. Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nature Genetics. 1997;17:18–19
  18. Miyamoto Y, Mabuchi A, Shi D, et al. A functional polymorphism in the 5 UTR of GDF5 is associated with susceptibility to osteoarthritis. Nature Genetics. 2007;39:529–533
  19. Erlacher L, Ng CK, Ullrich R, et al. Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthritis & Rheumatism. 1998;41:263–273
  20. Erlacher L, McCartney J, Piek E, et al. Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. Journal of Bone and Mineral Research. 1998;13:383–392
  21. Rountree RB, Schoor M, Chen H, et al. BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage. PLoS Biology. 2004;2:e355
  22. Lories RJ, Daans M, Matthys P, et al. Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis & Rheumatism. 2006;54:1736–1746
  23. Tylzanowski P, Mebis L, Luyten FP. The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects. Developmental Dynamics. 2006;235:1599–1607
  24. Fukui N, Zhu Y, Maloney WJ, et al. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. The Journal of Bone and Joint Surgery. American Volume. 2003;85A:59–66
  25. Lories RJ, Derese I, Ceuppens JL, et al. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis & Rheumatism. 2003;48:2807–2818
  26. van der Kraan PM, Vitters EL, van Beuningen HM, et al. Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. Osteoarthritis Cartilage. 2000;8:82–86
  27. Luyten FP, Dell Accio F, De Bari C. Skeletal tissue engineering: opportunities and challenges. Best Practice & Research. Clinical Rheumatology. 2002;
  28. Serra R, Johnson M, Filvaroff EH, et al. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. The Journal of Cell Biology. 1997;139:541–552
  29. Yang X, Chen L, Xu X, et al. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. The Journal of Cell Biology. 2001;153:35–46
  30. Glansbeek HL, van Beuningen HM, Vitters EL, et al. Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content. Arthritis & Rheumatism. 1997;40:1020–1028
  31. van Beuningen HM, Glansbeek HL, van der Kraan PM, et al. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage. 1998;6:306–317
  32. Bakker AC, van de Loo FA, van Beuningen HM, et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage. 2001;9:128–136
  33. Scharstuhl A, Glansbeek HL, van Beuningen HM, et al. Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. Journal of Immunology. 2002;169:507–514
  34. Scharstuhl A, Diepens R, Lensen J, et al. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Osteoarthritis and Cartilage. 2003;11:773–782
  35. Scharstuhl A, van Beuningen HM, Vitters EL, et al. Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Annals of the Rheumatic Diseases. 2002;61:1095–1098
  36. Hartmann C, Tabin CJ. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell. 2001;104:341–351
  37. Tamamura Y, Otani T, Kanatani N, et al. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. The Journal of Biological Chemistry. 2005;280:19185–19195
  38. Hens JR, Wilson KM, Dann P, et al. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. Journal of Bone and Mineral Research. 2005;20:1103–1113
  39. Hoang B, Moos M, Vukicevic S, et al. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. The Journal of Biological Chemistry. 1996;271:26131–26137
  40. Lin K, Wang S, Julius MA, et al. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:11196–11200
  41. Wang S, Krinks M, Lin K, et al. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell. 1997;88:757–766
  42. Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:9757–9762
  43. Valdes AM, Loughlin J, Oene MV, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis & Rheumatism. 2007;56:137–146
  44. Min JL, Meulenbelt I, Riyazi N, et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis & Rheumatism. 2005;52:1077–1080
  45. Lane NE, Lian K, Nevitt MC, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis & Rheumatism. 2006;54:1246–1254
  46. Lories RJ, Boonen S, Peeters J, et al. Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford). 2006;45:113–114
  47. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, et al. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Annals of the Rheumatic Diseases. 2007;66:1052–1055
  48. Lories RJ, Peeters J, Bakker A, et al. Deletion of frizzled related protein affects articular cartilage and biomechanical properties of the long bones. Arthritis & Rheumatism. 2007;56:4095–4103
  49. Zi X, Guo Y, Simoneau AR, et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Research. 2005;65:9762–9770
  50. Dell Accio F, De Bari C, El Tawil NM, et al. Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Research & Therapy. 2006;8:R139
  51. Chen L, Deng CX. Roles of FGF signaling in skeletal development and human genetic diseases. Frontiers in Bioscience. 2005;10:1961–1976
  52. Goldring MB, Tsuchimochi K, Ijiri K. The control of chondrogenesis. Journal of Cellular Biochemistry. 2006;97:33–44
  53. Vincent T, Hermansson M, Bolton M, et al. Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proceedings of the National Academy of Sciences of the United States of America. 2002;99:8259–8264
  54. Vincent TL, Hermansson MA, Hansen UN, et al. Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded. Arthritis & Rheumatism. 2004;50:526–533
  55. Vincent TL, McLean CJ, Full LE, et al. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage. 2007;15:752–763
  56. Hill CL, Hunter DJ, Niu J, et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Annals of the Rheumatic Diseases. 2007;
  57. Simkin PA. The musculoskeletal system: A. Joints. 1997;11:10–14
  58. McGonagle D, Lories RJ, Tan A, et al. The concept of a synovio-entheseal complex and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis & Rheumatism. 2007;56:2482–2491
  59. Da RR, Qin Y, Baeten D, et al. B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis. Journal of immunology. 2007;178:557–565
  60. Dequeker J, Aerssens J, Luyten FP. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clinical and Experimental Research. 2003;15:426–439
  61. Bodine PV, Zhao W, Kharode YP, et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Molecular Endocrinology. 2004;18:1222–1237
  62. Lories RJ, Luyten FP. Bone morphogenetic proteins in destructive and remodeling arthritis. Arthritis Research & Therapy. 2007;9:207
  63. Zoricic S, Maric I, Bobinac D, et al. Expression of bone morphogenetic proteins and cartilage-derived morphogenetic proteins during osteophyte formation in humans. Journal of Anatomy. 2003;202:269–277
  64. Nakase T, Miyaji T, Tomita T, et al. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage. 2003;11:278–284
  65. van Lent PL, Blom AB, van der KP, et al. Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis & Rheumatism. 2004;50:103–111
  66. Scharstuhl A, Vitters EL, van der Kraan PM, et al. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis & Rheumatism. 2003;48:3442–3451
  67. Lories RJU, Derese I, Luyten FP. Modulation of Bone Morphogenetic Protein signaling inhibits the onset and progression of ankylosing enthesitis. The Journal of Clinical Investigation. 2005;115:1571–1579

PII: S1521-6942(07)00134-9

doi: 10.1016/j.berh.2007.12.001

Best Practice & Research Clinical Rheumatology
Volume 22, Issue 2 , Pages 209-220 , April 2008

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