Best Practice & Research Clinical Rheumatology
Volume 22, Issue 3 , Pages 535-561 , June 2008

Dietary manipulation in musculoskeletal conditions

  • Margaret P. Rayman, BSc, DPhil (Oxon), RPHNutr (Professor of Nutritional Medicine)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +44 1483 686447; Fax: +44 1483 686401.

References 

  1. Panush R, Carter R, Katz P, et al. Diet therapy for rheumatoid arthritis. Arthritis and Rheumatism. 1983;26:462–471
  2. Garrett SL, Kennedy LG, Calin A. Patients' perceptions of disease modulation by diet in inflammatory (rheumatoid arthritis/ankylosing spondylitis) and degenerative joint disease. British Journal of Rheumatology. 1993;32:24
  3. Rayman MP, Callaghan A. Nutrition and arthritis. Oxford: Blackwell Publishing; 2006;
  4. Darlington LG, Ramsey NW, Mansfield JR. Placebo-controlled, blind study of dietary manipulation therapy in rheumatoid arthritis. Lancet. 1986;1:236–238
  5. Darlington LG, Ramsey NW. Review of dietary therapy for rheumatoid arthritis. British Journal of Rheumatology. 1993;32:507–514
  6. Haugen MA, Kjeldsen-Kragh J, Førre Ø. A pilot study of the effect of an elemental diet in the management of rheumatoid arthritis. Clinical and Experimental Rheumatology. 1994;12:275–279
  7. Kavanagh R, Workman E, Nash P, et al. The effects of elemental diet and subsequent food reintroduction on rheumatoid arthritis. British Journal of Rheumatology. 1995;34:270–273
  8. Podas T, Nightingale JMD, Oldham R, et al. Is rheumatoid arthritis a disease that starts in the intestine? A pilot study comparing an elemental diet with oral prednisolone. Postgraduate Medical Journal. 2007;83:128–131
  9. Udén A, Trang L, Venizelos N, Palmblad J. Neutrophil functions and clinical performance after total fasting in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. 1983;42:45–51
  10. Haugen M, Fraser D, Førre Ø. Diet therapy for the patient with rheumatoid arthritis?. Rheumatology (Oxford). 1999;38:1039–1044
  11. Müller H, de Toledo FW, Resch KL. Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scandinavian Journal of Rheumatology. 2001;30:1–10
  12. Sköldstam L, Hagfors L, Johansson G. An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. 2003;62:208–214
  13. McKellar G, Morrison E, McEntegart A, et al. A pilot study of a Mediterranean-type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow. Annals of the Rheumatic Diseases. 2007;66:1239–1243
  14. Hafström I, Ringertz B, Spångberg A, et al. A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens. Rheumatology (Oxford, England). 2001;40:1175–1179
  15. Cordain L, Toohey L, Smith MJ, Hickey MS. Modulation of immune function by dietary lectins in rheumatoid arthritis. The British Journal of Nutrition. 2000;83:207–217
  16. Peltonen R, Nenonen M, Helve T, et al. Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet. British Journal of Rheumatology. 1997;36:64–68
  17. Pusztai A. Dietary lectins are metabolic signals for the gut and modulate immune and hormone functions. European Journal of Clinical Nutrition. 1993;47:691–699
  18. Darlington LG. Joints and arthritic disease. In:  Brostoff J,  Challacombe SJ editor. Food allergy and intolerance. 2nd edn. London: WB Saunders; 2002;p. 747–760
  19. Zhang W, Doherty M, Bardin T, et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT). Annals of the Rheumatic Diseases. 2006;65:1312–1324
  20. Jordan KM, Cameron JS, Snaith M, et al. on behalf of the British Society for Rheumatology and British Health Professionals in Rheumatology Standards, Guidelines and Audit Working Group (SGAWG) British Society for Rheumatology and British Health Professionals in Rheumatology Guideline for the Management of Gout. Rheumatology (Oxford). 2007;
  21. Ebringer A, Wilson C. The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. Clinical Rheumatology. 1996;15(Suppl. 1):62–66
  22. Zochling J, van der Heijde D, Dougados M, et al. Current evidence for the management of ankylosing spondylitis: a systematic literature review for the ASAS/EULAR management recommendations in ankylosing spondylitis. Annals of the Rheumatic Diseases. 2006;65:423–432
  23. Morgan SL, Anderson AM, Hood SM, et al. Nutrient intake patterns, body mass index, and vitamin levels in patients with rheumatoid arthritis. Arthritis Care and Research. 1997;10:9–17
  24. Kaufmann J, Kielstein V, Kilian S, et al. Relation between body mass index and radiological progression in patients with rheumatoid arthritis. The Journal of Rheumatology. 2003;30:2350–2355
  25. Stavropoulos-Kalinoglou A, Metsiod GS, Koutedakis Y, et al. Redefining overweight and obesity in rheumatoid arthritis patients. Annals of the Rheumatic Diseases. 2007;66:1316–1321
  26. Dessein PH, Shipton EA, Stanwix AE, et al. Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Annals of the Rheumatic Diseases. 2000;59:539–543
  27. Fam AG. Gout, diet and the insulin resistance syndrome. The Journal of Rheumatology. 2002;29:1350–1355
  28. Marks R. Obesity profiles with knee osteoarthritis: correlation with pain, disability, disease progression. Obesity (Silver Spring, Md.). 2007;15:1867–1874
  29. Cooper C, Inskip H, Croft P, et al. Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity. American Journal of Epidemiology. 1998;147:516–522
  30. Liu B, Balkwill A, Banks E, et al. Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women. Rheumatology (Oxford, England). 2007;46:861–867
  31. Messier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis and Rheumatism. 2005;52:2026–2032
  32. Felson DT, Goggins J, Niu J, et al. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis and Rheumatism. 2004;50:3904–3909
  33. Reijman M, Pols HA, Bergink AP, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Annals of the Rheumatic Diseases. 2007;66:158–162
  34. Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Annals of Internal Medicine. 2000;133:635–646
  35. Creamer P, Hochberg MC. Osteoarthritis. Lancet. 1997;350:503–508
  36. Hauner H, Hochberg Z. Endocrinology of adipose tissue. Hormone and Metabolic Research. 2002;34:605–606
  37. Hauner H. Secretory factors from human adipose tissue and their functional role. The Proceedings of the Nutrition Society. 2005;64:163–169
  38. Fontana L, Eagon JC, Trujillo ME, et al. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007;56:1010–1013
  39. Toda Y, Toda T, Takemura S, et al. Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. The Journal of Rheumatology. 1998;25:2181–2186
  40. Wang Y, Wluka AE, English DR, et al. Body composition and knee cartilage properties in healthy, community-based adults. Annals of the Rheumatic Diseases. 2007;66:1244–1248
  41. Adam O. Anti-inflammatory diet in rheumatic diseases. European Journal of Clinical Nutrition. 1995;49:703–717
  42. Calder PC, Zurier RB. Polyunsaturated fatty acids and rheumatoid arthritis. Current Opinion in Clinical Nutrition and Metabolic Care. 2001;4:115–121
  43. MacLean CH, Mojica WA, Morton SC, et al. Effects of omega-3 fatty acids on lipids and glycemic control in Type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosis. Summary, Evidence Report/Technology Assessment No. 89. (prepared by the Southern California/RAND Evidence-based Practice Center, Los Angeles, CA.) AHRQ Publication No. 04-E012 Rockville, MD: Agency for Healthcare Research and Quality; March 2004;
  44. James MJ, Proudmann SM, Cleland LG. Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2003;68:399–405
  45. Yaqoob P, Pala HS, Cortina-Borja M, et al. Encapsulated fish oil enriched in alpha-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. European Journal of Clinical Investigation. 2000;30:260–274
  46. Calder PC. N-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. The American Journal of Clinical Nutrition. 2006;83(Suppl.):1505S–1519S
  47. Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007;129:210–223
  48. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gamma-linolenic acid. Annals of Internal Medicine. 1993;119:867–873
  49. Watson L, Byars ML, McGill P, et al. Cytokine and prostaglandin production by monocytes of volunteers and rheumatoid arthritis patients treated with dietary supplements of blackcurrant seed oils. British Journal of Rheumatology. 1993;32:1055–1058
  50. Little C, Parsons T. Herbal therapy for treating rheumatoid arthritis. Cochrane Database of Systematic Reviews (Online). 2001;1:p. CD002948
  51. Zurier RB, Rossetti RG, Jacobsen EW, et al. Gamma-linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis and Rheumatism. 1996;39:1808–1817
  52. Nordstrom DCE, Honkanen VEA, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis: a double-blind, placebo-controlled and randomized study: flaxseed vs safflower seed. Rheumatology International. 1995;14:231–234
  53. Ariza-Ariza R, Mestanza-Peralta M, Cardiel MH. Omega-3 fatty acids in rheumatoid arthritis: an overview. Seminars in Arthritis and Rheumatism. 1998;27:366–370
  54. Darlington LG, Stone TW. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. The British Journal of Nutrition. 2001;85:251–269
  55. Kremer JM. n-3 fatty acid supplements in rheumatoid arthritis. The American Journal of Clinical Nutrition. 2000;71:349S–351S
  56. Fortin PR, Lew RA, Liang MH, et al. Validation of a Meta-Analysis: the effects of fish oil in rheumatoid arthritis. Journal of Clinical Epidemiology. 1995;48:1379–1390
  57. Volker D, Fitzgerald P, Major G, et al. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. The Journal of Rheumatology. 2000;27:2343–2346
  58. Adam O, Beringer C, Kless T, et al. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Rheumatology International. 2003;23:27–36
  59. Sundrarjun T, Komindr S, Archararit N, et al. Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid arthritis. The Journal of International Medical Research. 2004;32:443–454
  60. Mead A, Atkinson D, Albin D, et al. on behalf of the UK Heart Health and Thoracic Dietitians Interest Group Dietetic guidelines on food and nutrition in the secondary prevention of cardiovascular disease – evidence from systematic reviews of randomized controlled trials. [second update, January 2006] Journal of Human Nutrition and Dietetics. 2006;19:401–419
  61. Cleland LG, James MJ. Fish oil and rheumatoid arthritis: antiinflammatory and collateral health benefits. The Journal of Rheumatology. 2000;27:2305–2307
  62. British Nutrition Foundation . Briefing paper: N-3 fatty acids and health. London: British Nutrition Foundation; 1999;
  63. Food Standards Agency . Survey of dioxins and dioxin-like PCBs in fish oil supplements. [Number 26/02] London: Food Standards Agency; 2002;
  64. Kris-Etherton PM, Taylor DS, Yu-Poth S, et al. Polyunsaturated fatty acids in the food chain in the United States. The American Journal of Clinical Nutrition. 2000;71:179–188
  65. UK Expert Group on Vitamins and Minerals . Safe upper levels for vitamins and minerals. London: Food Standards Agency; 2003;
  66. Beauchamp GK, Keast RS, Morel D, et al. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature. 2005;437:45–46
  67. Pattison DJ, Lunt M, Welch A, et al. Diet and disability in early inflammatory polyarthritis. Rheumatology. 2007;46(Suppl. 1):i122
  68. McAlindon TE, Felson DT, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?. Arthritis and Rheumatism. 1996;39:648–656
  69. Canter PH, Wider B, Ernst E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology (Oxford, England). 2007;46:1223–1233
  70. Scherak O, Kolarz MD. Vitamin E and rheumatoid arthritis. Arthritis and Rheumatism. 1991;34:1205–1206
  71. Edmonds SE, Winyard PG, Guo R, et al. Durative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo-controlled double-blind trial. Annals of the Rheumatic Diseases. 1997;56:649–655
  72. Wittenborg A, Petersen G, Lorkowski G, Brabant T. Effectiveness of vitamin E in comparison with diclofenac sodium in treatment of patients with chronic polyarthritis. Zeitschrift für Rheumatologie. 1998;57:215–221[in German]
  73. Food Standards Agency . McCance & Widdowson's the composition of foods. 6th Summary ed.. Cambridge: Royal Society of Chemistry; 2002;
  74. Brigelius-Flohé R, Banning A, Schnurr K. Selenium-dependent enzymes in endothelial function. Antioxidants & Redox Signaling. 2003;5:205–215
  75. Vunta H, Davis F, Palempalli UD, et al. The Anti-inflammatory Effects of Selenium Are Mediated through 15-Deoxy-{Delta}12,14-prostaglandin J2 in Macrophages. The Journal of Biological Chemistry. 2007;282:17964–17973
  76. Arteel GE, Briviba K, Sies H. Protection against peroxynitrite. FEBS Letters. 1999;445:226–230
  77. Yoon SO, Kim MM, Chung AS. Inhibitory effect of selenite on invasion of HT1080 tumor cells. The Journal of Biological Chemistry. 2001;276:20085–20092
  78. Jiang C, Jiang W, Ip C, et al. Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake. Molecular Carcinogenesis. 1999;26:213–225
  79. Jordan J, Fang F, Arab L, et al. Low selenium levels are associated with increased risk for osteoarthritis of the knee. Abstract no. 1189, American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, 2005; November 12–17, San Diego, California.
  80. Peretz A, Neve J, Duchateau J, Famaey JP. Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations. British Journal of Rheumatology. 1992;31:281–286
  81. Heinle K, Adam A, Gradl M, et al. Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium. Medizinische Klinik (Munich). 1997;92(Suppl. 3):29–31[in German]
  82. Aaseth J, Haugen M, Førre Ø. Rheumatoid arthritis and metal compounds – perspectives on the role of oxygen radical detoxification. Analyst. 1998;123:3–6
  83. Rayman MP. The use of high-selenium yeast to raise selenium status: how does it measure up?. The British Journal of Nutrition. 2004;92:557–573
  84. Rayman MP. The importance of selenium to human health. Lancet. 2000;356:233–241
  85. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18:872–879
  86. Johnson AR, Pavlovsky AG, Ortwine DF, et al. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. The Journal of Biological Chemistry. 2007;282:27781–27791
  87. O'Dell B. Roles for iron and copper in connective tissue biosynthesis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1981;294:91–104
  88. Brewer GJ. Anti-copper therapy against cancer and diseases of inflammation and fibrosis. Drug Discovery Today. 2005;10:1103–1109
  89. Omoto A, Kawahito Y, Prudovsky I, et al. Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats. Arthritis Research & Therapy. 2005;7:R1174–R1182
  90. Stone J, Doube A, Dudson D, Wallace J. Inadequate calcium, folic acid, vitamin E, zinc, and selenium intake in rheumatoid arthritis patients: results of a dietary survey. Seminars in Arthritis and Rheumatism. 1997;27:180–185
  91. Peretz A, Neve J, Jeghers O, Pelen F. Zinc distribution in blood components, inflammatory status and clinical indexes of disease activity during zinc supplementation in inflammatory rheumatic diseases. The American Journal of Clinical Nutrition. 1993;57:690–694
  92. Naveh Y, Schapira D, Ravel Y, et al. Zinc metabolism in rheumatoid arthritis: plasma and urinary zinc and relationship to disease activity. The Journal of Rheumatology. 1997;24:643–646
  93. Shenkin A. Trace elements and inflammatory response: implications for nutritional support. Nutrition. 1995;11(Suppl. 1):100–105
  94. DiSilvestro RA, Marten J, Skehan M. Effects of copper supplementation on ceruloplasmin and copper-zinc superoxide dismutase in free-living rheumatoid arthritis patients. Journal of the American College of Nutrition. 1992;11:177–180
  95. Bae S-C, Kim S-J, Sung M-K. Inadequate antioxidant nutrient intake and altered plasma antioxidant status of rheumatoid arthritis patients. Journal of the American College of Nutrition. 2003;22:311–315
  96. Simkin PA. Zinc sulphate in rheumatoid arthritis. Progress in Clinical and Biological Research. 1977;14:343–356
  97. Bates CJ, Prentice A, Cole TJ, et al. Micronutrients: highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over. The British Journal of Nutrition. 1999;82:7–15
  98. Henderson L, Irving K, Gregory J, et al. Food Standards Agency. The National Diet & Nutrition Survey: adults aged 19 to 64 years. www.statistics.gov.uk/downloads/theme_health/NDNS2003;
  99. Berger A. What does zinc do?. British Medical Journal. 2002;325:1062–1063
  100. Blake DR, Merry P, Stevens C, et al. Iron free radicals and arthritis. The Proceedings of the Nutrition Society. 1990;49:239–245
  101. Wilson A, Yu HT, Goodnough LT, Nissenson AR. Prevalence and outcomes of anaemia in rheumatoid arthritis: a systematic review of the literature. The American Journal of Medicine. 2004;116(Suppl. 7A):50S–57S
  102. Punnonen K, Kaipiainen-Seppanen O, Riittinen L, et al. Evaluation of iron status in anemic patients with rheumatoid arthritis using an automated immunoturbidimetric assay for transferrin receptor. Clinical Chemistry and Laboratory Medicine. 2000;38:1297–1300
  103. Fitzsimons EJ, Sturrock RD. The chronic anaemia of rheumatoid arthritis: iron banking or blocking?. Lancet. 2002;360:1713–1714
  104. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence?. The British Journal of Nutrition. 2003;89:552–572
  105. Scharla SH, Schacht E, Lempert UG. Alfacalcidol versus plain vitamin D in inflammation induced bone loss. The Journal of Rheumatology. 2005;76(Suppl.):26–32
  106. Maalej A, Petit-Teixeira E, Michou L, et al. Association study of VDR gene with rheumatoid arthritis in the French population. Genes and Immunity. 2005;6:707–711
  107. Garcia-Lozano JR, Gonzalez-Escribano MF, Valenzuela A, et al. Association of vitamin D receptor genotypes with early onset rheumatoid arthritis. European Journal of Immunogenetics. 2001;28:89–93
  108. Gomez-Vaquero C, Fiter J, Enjuanes A, et al. Influence of the BsmI polymorphism of the vitamin D receptor gene on rheumatoid arthritis clinical activity. The Journal of Rheumatology. 2007;34:1823–1826
  109. Gough A, Sambrook P, Devlin J, et al. Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis. The Journal of Rheumatology. 1998;25:864–868
  110. Keen RW, Hart DJ, Lanchbury JS, Spector TD. Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene. Arthritis and Rheumatism. 1997;40:1444–1449
  111. Uitterlinden AG, Burger H, van Duijn CM, et al. Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee. Arthritis and Rheumatism. 2000;43:1456–1464
  112. Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Experimental Biology and Medicine (Maywood, N.J.). 2004;229:1136–1142
  113. Merlino LA, Curtis J, Mikulus TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis and Rheumatism. 2004;50:72–77
  114. Oelzner P, Müller A, Deschner F, et al. Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis. Calcified Tissue International. 1998;62:193–198
  115. Patel S, Farragher T, Berry J, et al. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis and Rheumatism. 2007;56:2143–2149
  116. DeLuca HF, Cantorna MT. Vitamin D: its role and uses in immunology. The FASEB Journal. 2001;15:2579–2585
  117. Brohult J, Jonson B. Effects of large doses of calciferol on patients with rheumatoid arthritis. A double-blind clinical trial. Scandinavian Journal of Rheumatology. 1973;2:173–176
  118. Dottori L, D'Ottavio D, Brundisini B. Calcifediol and calcitonin in the therapy of rheumatoid arthritis. A short-term controlled study. Minerva Medica. 1982;73:3033–3040
  119. Andjelkovic Z, Vojinovic J, Pejnovic N, et al. Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients. Clinical and Experimental Rheumatology. 1999;17:453–456
  120. Hypponen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. The American Journal of Clinical Nutrition. 2007;85:860–868
  121. Holick MF. Vitamin D deficiency. The New England Journal of Medicine. 2007;357:266–281
  122. McAlindon T, Felson DT. Nutrition: risk factors for osteoarthritis. Annals of the Rheumatic Diseases. 1997;56:397–402
  123. McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Annals of Internal Medicine. 1996;125:353–359
  124. Lane NE, Gore LR, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group. Arthritis and Rheumatism. 1999;42:854–860
  125. Felson DT, Niu J, Clancy M, et al. Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies. Arthritis and Rheumatism. 2007;56:129–136
  126. Cantorna MT, Mahon BD. D-hormone and the immune system. The Journal of Rheumatology. 2005;76(Suppl.):11–20
  127. Bischoff-Ferrari HA, Zhang Y, Kiel DP, Felson DT. Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis and Rheumatism. 2005;53:821–826
  128. Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. The Journal of Clinical Endocrinology and Metabolism. 2004;89:5387–5391

PII: S1521-6942(07)00143-X

doi: 10.1016/j.berh.2007.12.010

Best Practice & Research Clinical Rheumatology
Volume 22, Issue 3 , Pages 535-561 , June 2008