Best Practice & Research Clinical Rheumatology
Volume 22, Issue 5 , Pages 863-882, October 2008

Hypereosinophilic syndromes

  • Loïc Guillevin, MD

      Affiliations

    • Corresponding Author InformationCorresponding author. Assistance Publique Hôpitaux de Paris, Université Paris Descartes, 27 Rue du Faubourg St. Jacques, 75679 Paris Cedex 14, France. Tel.: +33 1 58 41 13 21; Fax: +33 1 58 41 14 60.

French Eosinophil Network, Department of Immunology, CHRU de Lille, Université Lille, Lille, France

Department of Internal Medicine, Hôpital Foch, Université Versailles Saint-Quentin-en-Yvelines, Suresnes, France

Department of Internal Medicine, Hôpital Foch, Université Versailles Saint-Quentin-en-Yvelines, Suresnes, France

Department of Internal Medicine, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, Université Paris Descartes, Paris, France

Hypereosinophilia (>0.5×109/L) is a common clinical finding that can be secondary to a large variety of diseases (helminth infections, allergic diseases, drug reactions, specific organ disease, malignancies, systemic diseases). When a complete evaluation of a chronic hypereosinophilia fails to reveal an underlying disease, the diagnosis of hypereosinophilic syndrome (HES) or Churg–Strauss syndrome (CSS) is suggested.

Key words: Churg-Strauss syndrome, eosinophilia, hypereosinophilic syndrome, mepolizumab, physiopathology, treatment, tyrosine kinase

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PII: S1521-6942(08)00110-1

doi:10.1016/j.berh.2008.09.010

Best Practice & Research Clinical Rheumatology
Volume 22, Issue 5 , Pages 863-882, October 2008

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