Best Practice & Research Clinical Rheumatology
Volume 22, Issue 6 , Pages 1019-1044 , December 2008

Imaging in rheumatoid arthritis – status and recent advances for magnetic resonance imaging, ultrasonography, computed tomography and conventional radiography

  • Mikkel Østergaard, MD, PhD, DMSc (Professor in Rheumatology/Arthritis)

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark. Tel.: +45 21603865/36322839; Fax: +45 36471410.

References 

  1. Brower AC. Use of the radiograph to measure the course of rheumatoid arthritis. The gold standard versus fool's gold. Arthritis and Rheumatism. 1990;33:316–324
  2. McQueen FM, Stewart N, Crabbe J, et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosion at four months after symptom onset. Annals of the Rheumatic Diseases. 1998;57:350–356
  3. Backhaus M, Kamradt T, Sandrock D, et al. Arthritis of the finger joints. A comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging. Arthritis and Rheumatism. 1999;42:1232–1245
  4. Klarlund M, Østergaard M, Jensen KE, et al. Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis. Annals of the Rheumatic Diseases. 2000;59:521–528
  5. Lindegaard H, Vallø J, Hørslev-Petersen K, et al. Low field dedicated magnetic resonance imaging in untreated rheumatoid arthritis of recent onset. Annals of the Rheumatic Diseases. 2001;60:770–776
  6. Grassi W, Tittarelli E, Pirani O, et al. Ultrasound examination of metacarpophalangeal joints in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 1993;22:243–247
  7. Watt I. Basic differential diagnosis of arthritis. European Radiology. 1997;7:344–351
  8. Scott DL, Pugner K, Kaarela K, et al. The links between joint damage and disability in rheumatoid arthritis. Rheumatology (Oxford, England). 2000;39:122–132
  9. van der Heijde DMFM. Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillière’s Clinical Rheumatology. 1996;10:435–453
  10. McQueen FM, Stewart N, Crabbe J, et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Annals of the Rheumatic Diseases. 1999;58:156–163
  11. Østergaard M. Magnetic resonance imaging in rheumatoid arthritis. Quantitative methods for assessment of the inflammatory process in peripheral joints. Danish Medical Bulletin. 1999;46:313–344
  12. Backhaus M, Burmester GR, Sandrock D, et al. Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints. Annals of the Rheumatic Diseases. 2002;61:895–904
  13. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism. 1988;31:315–324
  14. Kaarela K. Prognostic factors and diagnostic criteria in early rheumatoid arthritis. Scandinavian Journal of Rheumatology. 1985;14(Suppl. 57):1–54
  15. Ødegård S, Landewe R, Van Der HD, et al. Association of early radiographic damage with impaired physical function in rheumatoid arthritis: a ten-year, longitudinal observational study in 238 patients. Arthritis and Rheumatism. 2006;54:68–75
  16. Visser H, le Cessie S, Vos K, et al. How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis and Rheumatism. 2002;46:357–365
  17. Nissilä M, Isomaki H, Kaarela K, et al. Prognosis of inflammatory joint diseases. A three-year follow-up study. Scandinavian Journal of Rheumatology. 1983;12:33–38
  18. Möttönen TT. Prediction of erosiveness and rate of development of new erosions in early rheumatoid arthritis. Annals of the Rheumatic Diseases. 1988;47:648–653
  19. van der Heijde DMFM, van Leeuwen MA, van Riel PLCM, et al. Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis. Arthritis and Rheumatism. 1992;35:26–34
  20. van der Heijde DMFM. Joint erosions and patients with early rheumatoid arthritis. British Journal of Rheumatology. 1995;34(Suppl. 2):74–78
  21. Paulus HE, Oh M, Sharp JT, et al. Correlation of single time-point damage scores with observed progression of radiographic damage during the first 6 years of rheumatoid arthritis. The Journal of Rheumatology. 2003;30:705–713
  22. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines . Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis and Rheumatism. 2002;46:328–346
  23. Sharp JT, Young DY, Bluhm GB, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?. Arthritis and Rheumatism. 1985;28:1326–1335
  24. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiologica: Diagnosis. 1977;18:481–491
  25. van der Heijde D. Quantification of radiological damage in inflammatory arthritis: rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Best Practice & Research. Clinical Rheumatology. 2004;18:847–860
  26. Bruynesteyn K, Landewe R, van der LS, et al. Radiography as primary outcome in rheumatoid arthritis: acceptable sample sizes for trials with 3 months' follow up. Annals of the Rheumatic Diseases. 2004;63:1413–1418
  27. van der Heijde D, Dankert T, Nieman F, et al. Reliability and sensitivity to change of a simplification of the Sharp/van der Heijde radiological assessment in rheumatoid arthritis. Rheumatology (Oxford, England). 1999;38:941–947
  28. Dias EM, Lukas C, Landewe R, et al. Reliability and sensitivity to change of the simple erosion narrowing score compared with the Sharp–van der Heijde method for scoring radiographs in rheumatoid arthritis. Annals of the Rheumatic Diseases. 2008;67:375–379
  29. Alasaarela E, Suramo I, Tervonen O, et al. Evaluation of humoral head erosions in rheumatoid arthitis: a comparison of ultrasonography, magnetic resonance imaging, computed tomography and plain radiography. British Journal of Rheumatology. 1998;37:1152–1156
  30. Døhn UM, Ejbjerg BJ, Court-Payen , et al. Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints. Arthritis Research & Therapy. 2006;8:R110
  31. Perry D, Stewart N, Benton N, et al. Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning. The Journal of Rheumatology. 2005;32:256–267
  32. Yao L, Magalnick M, Wilson M, et al. Periarticular bone findings in rheumatoid arthritis: T2-weighted versus contrast-enhanced T1-weighted MRI. AJR. American Journal of Roentgenology. 2006;187:358–363
  33. Døhn UM, Ejbjerg BJ, Hasselquist M, et al. Rheumatoid arthritis bone erosion volumes on CT and MRI: reliability and correlations with erosion scores on CT, MRI and radiography. Annals of the Rheumatic Diseases. 2007;66:1388–1392
  34. Døhn UM, Ejbjerg BJ, Hasselquist M, et al. Detection of bone erosions in rheumatoid arthritis wrist joints with magnetic resonance imaging, computed tomography and radiography. Arthritis Research & Therapy. 2008;10:R25
  35. Møller Døhn U, Boonen A, Hetland ML, et al. Erosive progression is minimal, but erosion healing rare, in RA patients treated with adalimumab. A 1-year longitudinal investigator-initiated study using high resolution computed tomography (CT) as the primary outcome measure. Annals of the Rheumatic Diseases. 2008;67(Suppl. 2):122–123
  36. König H, Sieper J, Wolf KJ. Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with dynamic MR imaging enhanced with gd-DTPA. Radiology. 1990;176:473–477
  37. Østergaard M, Stoltenberg M, Løvgreen-Nielsen P, et al. Magnetic resonance imaging-determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium. Arthritis and Rheumatism. 1997;40:1856–1867
  38. Østergaard M, Stoltenberg M, Løvgreen-Nielsen P, et al. Quantification of synovitis by MRI: correlation between dynamic and static gadolinium-enhanced magnetic resonance imaging and microscopic and macroscopic signs of synovial inflammation. Magnetic Resonance Imaging. 1998;16:743–754
  39. Ostendorf B, Peters R, Dann P, et al. Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis. Arthritis and Rheumatism. 2001;44:2492–2502
  40. McQueen FM, Gao A, Østergaard M, et al. High grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone. Annals of the Rheumatic Diseases. 2007;[published online]
  41. Jimenez-Boj E, Nobauer-Huhmann I, Hanslik-Schnabel B, et al. Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. Arthritis and Rheumatism. 2007;56:1118–1124
  42. Ejbjerg BJ, Vestergaard A, Jacobsen S, et al. The smallest detectable difference and sensitivity to change of magnetic resonance imaging and radiographic scoring of structural joint damage in rheumatoid arthritis finger, wrist, and toe joints: a comparison of the OMERACT rheumatoid arthritis magnetic resonance imaging score applied to different joint combinations and the Sharp/van der Heijde radiographic score. Arthritis and Rheumatism. 2005;52:2300–2306
  43. Savnik A, Malmskov H, Thomsen HS, et al. MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T). European Radiology. 2001;11:1030–1038
  44. Olech E, Freeston JE, Conaghan PG, et al. Using extremity magnetic resonance imaging to assess and monitor early rheumatoid arthritis: the optimal joint combination to be scanned in clinical practice. The Journal of Rheumatology. 2008;35:580–583
  45. Crues JV, Shellock FG, Dardashti S, et al. Identification of wrist and metacarpophalangeal joint erosions using a portable magnetic resonance imaging system compared to conventional radiographs. The Journal of Rheumatology. 2004;31:676–685
  46. Taouli B, Zaim S, Peterfy CG, et al. Rheumatoid arthritis of the hand and wrist: comparison of three imaging techniques. AJR. American Journal of Roentgenology. 2004;182:937–943
  47. Ejbjerg BJ, Narvestad E, Jacobsen S, et al. Optimised, low cost, low field dedicated extremity MRI is highly specific and sensitive for synovitis and bone erosions in rheumatoid arthritis wrist and finger joints: comparison with conventional high field MRI and radiography. Annals of the Rheumatic Diseases. 2005;64:1280–1287
  48. Chen TS, Crues JV, Ali M, et al. Magnetic resonance imaging is more sensitive than radiographs in detecting change in size of erosions in rheumatoid arthritis. The Journal of Rheumatology. 2006;33:1957–1967
  49. Schirmer C, Scheel AK, Althoff CE, et al. Diagnostic quality and scoring of synovitis, tenosynovitis and erosions in low-field MRI of patients with rheumatoid arthritis: a comparison with conventional MRI. Annals of the Rheumatic Diseases. 2007;66:522–529
  50. Freeston JE, Conaghan PG, Dass S, et al. Does extremity-MRI improve erosion detection in severely damaged joints? A study of long-standing rheumatoid arthritis using three imaging modalities. Annals of the Rheumatic Diseases. 2007;66:1538–1540
  51. Duer-Jensen A, Vestergaard A, Døhn UM, et al. Detection of rheumatoid arthritis bone erosions by two different dedicated extremity MRI units and conventional radiography. Annals of the Rheumatic Diseases. 2008;67:998–1003
  52. Duer A, Ejbjerg B, Albrecht-Beste E, et al. Does dedicated extremity MRI reliably detect RA bone erosions? A comparison with high resolution CT. Annals of the Rheumatic Diseases. 2007;66(Suppl. 2):563
  53. Østergaard M, Conaghan PG, O‘Connor P, et al. Reducing invasiveness, duration and costs of MRI in rheumatoid arthritis by omitting intravenous contrast injection - does it change the assessment of inflammatory and destructive joint changes by the OMERACT RAMRIS? The Journal of Rheumatology 2008, in press
  54. Østergaard M, Peterfy C, Conaghan P, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. The Journal of Rheumatology. 2003;30:1385–1386
  55. Boers M, Brooks P, Strand CV, et al. The OMERACT filter for outcome measures in rheumatology. The Journal of Rheumatology. 1998;25:198–199
  56. Østergaard M, Klarlund M, Lassere M, et al. Interreader agreement in the assessment of magnetic resonance images of rheumatoid arthritis wrist and finger joints – an international multicenter study. The Journal of Rheumatology. 2001;28:1143–1150
  57. Conaghan P, Lassere M, Østergaard M, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Exercise 4: an international multicenter longitudinal study using the RA-MRI score. The Journal of Rheumatology. 2003;30:1376–1379
  58. Lassere M, McQueen F, Østergaard M, et al. OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Exercise 3: an international multicenter reliability study using the RA-MRI score. The Journal of Rheumatology. 2003;30:1366–1375
  59. Haavardsholm EA, Østergaard M, Ejbjerg BJ, et al. Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting. Arthritis and Rheumatism. 2005;52:3860–3867
  60. Bird P, Joshua F, Lassere M, et al. Training and calibration improve inter-reader reliability of joint damage assessment using magnetic resonance image scoring and computerized erosion volume measurement. The Journal of Rheumatology. 2005;32:1452–1458
  61. Østergaard M, Edmonds J, McQueen F, et al. The EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. Annals of the Rheumatic Diseases. 2005;64(Suppl. 1):i2–i55
  62. Haavardsholm EA, Østergaard M, Ejbjerg BJ, et al. Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study. Annals of the Rheumatic Diseases. 2007;66:1216–1220
  63. Ejbjerg B. Magnetic resonance imaging in rheumatoid arthritis. A study of aspects of joint selection, contrast agent use and type of MRI unit. PhD dissertation. Copenhagen: University of Copenhagen, 2005.
  64. Døhn UM, Skjødt H, Hetland ML, et al. No erosive progression revealed by MRI in rheumatoid arthritis patients treated with etanercept, even in patients with persistent MRI and clinical signs of joint inflammation. Clinical Rheumatology. 2007;26:1857–1861
  65. Lisbona MP, Maymo J, Perich J, et al. Etanercept reduces synovitis as measured by magnetic resonance imaging in patients with active rheumatoid arthritis after only 6 weeks. The Journal of Rheumatology. 2008;35:394–397
  66. Quinn MA, Conaghan PG, O'Connor PJ, et al. Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis and Rheumatism. 2005;52:27–35
  67. Zikou AK, Argyropoulou MI, Voulgari PV, et al. Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with adalimumab. The Journal of Rheumatology. 2006;33:219–223
  68. Argyropoulou MI, Glatzouni A, Voulgari PV, et al. Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with infliximab. Joint, Bone, Spine. 2005;72:557–561
  69. Møller Døhn U, Bird P, Østergaard M, et al. Rheumatoid arthritis patients treated with rituximab for one year showed no mean erosive progression, but a small tendency towards regression, on MRI and conventional radiography 1 year after treatment. Annals of the Rheumatic Diseases. 2008;67(Suppl. 2):107
  70. Østergaard M, Duer A, Nielsen H, et al. Magnetic resonance imaging for accelerated assessment of drug effect and prediction of subsequent radiographic progression in rheumatoid arthritis: a study of patients receiving combined anakinra and methotrexate treatment. Annals of the Rheumatic Diseases. 2005;64:1503–1506
  71. Haavardsholm EA, Østergaard M, Bøyesen P, et al. Monitoring treatment in RA: magnetic resonance imaging of inflammatory lesions is more responsive than conventional measures of disease activity. Annals of the Rheumatic Diseases. 2008;67(Suppl. 2):561–562
  72. Østergaard M, Stoltenberg M, Henriksen O, et al. Quantitative assessment of synovial inflammation by dynamic gadolinium-enhanced magnetic resonance imaging. A study of the effect of intra-articular methylprednisolone on the rate of early synovial enhancement. British Journal of Rheumatology. 1996;35:50–59
  73. Kubassova O. Automatic segmentation of blood vessels from dynamic MRI datasets. Medical Image Computing and Computer-assisted Intervention. 2007;10:593–600
  74. Kubassova OA, Boyle RD, Radjenovic A. Quantitative analysis of dynamic contrast-enhanced MRI datasets of the metacarpophalangeal joints. Academic Radiology. 2007;14:1189–1200
  75. Hodgson RJ, Connolly S, Barnes T, et al. Pharmacokinetic modeling of dynamic contrast-enhanced MRI of the hand and wrist in rheumatoid arthritis and the response to anti-tumor necrosis factor-alpha therapy. Magnetic Resonance in Medicine. 2007;58:482–489
  76. Hodgson RJ, Barnes T, Connolly S, et al. Changes underlying the dynamic contrast-enhanced MRI response to treatment in rheumatoid arthritis. Skeletal Radiology. 2008;37:201–207
  77. Tripoliti EE, Fotiadis DI, Argyropoulou M. Automated segmentation and quantification of inflammatory tissue of the hand in rheumatoid arthritis patients using magnetic resonance imaging data. Artificial Intelligence in Medicine. 2007;40:65–85
  78. Ejbjerg BJ, Østergaard M, Jurik AG, et al. No additional effect of cyclosporine on MRI-determined synovitis and bone damage in early rheumatoid arthritis patients treated with methorexate and intraarticular bethamethasone results from a 12-month randomised double blind placebo-controlled trial. Annals of the Rheumatic Diseases. 2005;64(Suppl. 3):88–89
  79. Jarrett SJ, Conaghan PG, Sloan VS, et al. Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis. Arthritis and Rheumatism. 2006;54:1410–1414
  80. Durez P, Malghem J, Nzeusseu TA, et al. Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone. Arthritis and Rheumatism. 2007;56:3919–3927
  81. Cohen SB, Dore RK, Lane NE, et al. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis and Rheumatism. 2008;58:1299–1309
  82. Sugimoto H, Takeda A, Hyodoh K. Early stage rheumatoid arthritis: prospective study of the effectiveness of MR imaging for diagnosis. Radiology. 2000;216:569–575
  83. Boutry N, Hachulla E, Flipo R-M, et al. MR imaging involvement of the hands in early rheumatoid arthritis: comparison with systemic lupus erythematosus and primary Sjogren syndrome. European Radiology. 2005;15(Suppl. 1):262
  84. Solau-Gervais E, Legrand JL, Cortet B, et al. Magnetic resonance imaging of the hand for the diagnosis of rheumatoid arthritis in the absence of anti-cyclic citrullinated peptide antibodies: a prospective study. The Journal of Rheumatology. 2006;33:1760–1765
  85. Tamai M, Kawakami A, Uetani M, et al. Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination. Annals of the Rheumatic Diseases. 2006;65:134–135
  86. Duer A, Østergaard M, Hørslev-Petersen K, et al. Magnetic resonance imaging and bone scintigraphy in the differential diagnosis of unclassified arthritis. Annals of the Rheumatic Diseases. 2008;67:48–51
  87. Narvaez J, Sirvent E, Antonio NJ, et al. Usefulness of magnetic resonance imaging of the hand versus anticyclic citrullinated peptide antibody testing to confirm the diagnosis of clinically suspected early rheumatoid arthritis in the absence of rheumatoid factor and radiographic erosions. Seminars in Arthritis and Rheumatism. 2008;
  88. Savnik A, Malmskov H, Thomsen HS, et al. MRI of the wrist and finger joints in inflammatory joint diseases at 1-year interval: MRI features to predict bone erosions. European Radiology. 2002;12:1203–1210
  89. McQueen FM, Benton N, Perry D, et al. Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis. Arthritis and Rheumatism. 2003;48:1814–1827
  90. Palosaari K, Vuotila J, Takalo R, et al. Bone oedema predicts erosive progression on wrist MRI in early RA – a 2-yr observational MRI and NC scintigraphy study. Rheumatology (Oxford, England). 2006;
  91. Tanaka N, Sakahashi H, Ishii S, et al. Synovial membrane enhancement and bone erosion by magnetic resonance imaging for prediction of radiologic progression in patients with early rheumatoid arthritis. Rheumatology International. 2005;25:103–107
  92. Lindegaard HM, Vallø J, Hørslev-Petersen K, et al. Low-cost, low-field dedicated extremity magnetic resonance imaging in early rheumatoid arthritis: a 1-year follow-up study. Annals of the Rheumatic Diseases. 2006;65:1208–1212
  93. Haavardsholm EA, Boyesen P, Østergaard M, et al. Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression. Annals of the Rheumatic Diseases. 2008;67:794–800
  94. Hetland ML, Ejbjerg BJ, Horslev-Petersen K, et al. MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2 year randomized controlled trial (CIMESTRA). Annals of the Rheumatic Diseases. 2008;
  95. Benton N, Stewart N, Crabbe J, et al. MRI of the wrist in early rheumatoid arthritis can be used to predict functional outcome at 6 years. Annals of the Rheumatic Diseases. 2004;63:555–561
  96. Zheng S, Robinson E, Yeoman S, et al. MRI bone oedema predicts eight year tendon function at the wrist but not the requirement for orthopaedic surgery in rheumatoid arthritis. Annals of the Rheumatic Diseases. 2006;65:607–611
  97. McQueen F, Beckley V, Crabbe J, et al. Magnetic resonance imaging evidence of tendinopathy in early rheumatoid arthritis predicts tendon rupture at six years. Arthritis and Rheumatism. 2005;52:744–751
  98. Brown AK, Quinn MA, Karim Z, et al. Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. Arthritis and Rheumatism. 2006;54:3761–3773
  99. Martinez-Martinez MU, Cuevas-Orta E, Reyes-Vaca G, et al. Magnetic resonance imaging in patients with rheumatoid arthritis with complete remission treated with disease-modifying antirheumatic drugs or anti-tumour necrosis factor alpha agents. Annals of the Rheumatic Diseases. 2007;66:134–135
  100. Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis and Rheumatism. 2008;58:2958–2967
  101. Brown AK, Conaghan PG, Karim Z, et al. The relevance of sub-clinical synovitis in the longitudinal assessment of RA: MRI-detected inflammation predicts structural progression in patients in apparent clinical remission. Arthritis and Rheumatism. 2006;54:L4
  102. Grassi W, Cervini C. Ultrasonography in rheumatology: an evolving technique. Annals of the Rheumatic Diseases. 1998;57:268–271
  103. Newman JS, Laing TJ, McCarthy TJ, et al. Power Doppler sonography of synovitis: assessment of therapeutic response – preliminary observations. Radiology. 1996;198:582–584
  104. Szkudlarek M, Court-Payen , Strandberg C, et al. Power Doppler ultrasonography for assessment of synovitis in the metacarpophalangeal joints of patients with rheumatoid arthritis: a comparison with dynamic magnetic resonance imaging. Arthritis and Rheumatism. 2001;44:2018–2023
  105. Hau M, Schultz H, Tony H-P, et al. Evaluation of pannus and vascularization of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis by high-resolution ultrasound (multidimensional linear array). Arthritis and Rheumatism. 1999;42:2303–2308
  106. Ferrell WR, Balint PV, Egan CG, et al. Metacarpophalangeal joints in rheumatoid arthritis: laser Doppler imaging – initial experience. Radiology. 2001;220:257–262
  107. Qvistgaard E, Rogind H, Torp-Pedersen S, et al. Quantitative ultrasonography in rheumatoid arthritis: evaluation of inflammation by Doppler technique. Annals of the Rheumatic Diseases. 2001;60:690–693
  108. Taylor PC. VEGF and imaging of vessels in rheumatoid arthritis. Arthritis Research. 2002;4(Suppl. 3):S99–S107
  109. Hau M, Kneitz C, Tony HP, et al. High resolution ultrasound detects a decrease in pannus vascularisation of small finger joints in patients with rheumatoid arthritis receiving treatment with soluble tumour necrosis factor alpha receptor (etanercept). Annals of the Rheumatic Diseases. 2002;61:55–58
  110. Terslev L, Torp-Pedersen S, Qvistgaard E, et al. Estimation of inflammation by Doppler ultrasound: quantitative changes after intra-articular treatment in rheumatoid arthritis. Annals of the Rheumatic Diseases. 2003;62:1049–1053
  111. Walther M, Harms H, Krenn V, et al. Correlation of power Doppler sonography with vascularity of synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis. Arthritis and Rheumatism. 2001;44:331–338
  112. Walther M, Harms H, Krenn V, et al. Synovial tissue of the hip at power Doppler US: correlation between vascularity and power Doppler US signal. Radiology. 2002;225:225–231
  113. Terslev L, Torp-Pedersen S, Savnik A, et al. Doppler ultrasound and magnetic resonance imaging of synovial inflammation of the hand in rheumatoid arthritis: a comparative study. Arthritis and Rheumatism. 2003;48:2434–2441
  114. Szkudlarek M, Narvestad E, Klarlund M, et al. Ultrasonography of the metatarsophalangeal joints in rheumatoid arthritis, compared with magnetic resonance imaging, conventional radiography and clinical examination. Arthritis and Rheumatism. 2004;50:2103–2112
  115. Scheel AK, Hermann KG, Kahler E, et al. A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis. Arthritis and Rheumatism. 2005;52:733–743
  116. Szkudlarek M, Klarlund M, Narvestad E, et al. Ultrasonography of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination. Arthritis Research & Therapy. 2006;8:R52
  117. Strunk J, Klingenberger P, Strube K, et al. Three-dimensional Doppler sonographic vascular imaging in regions with increased MR enhancement in inflamed wrists of patients with rheumatoid arthritis. Joint, Bone, Spine. 2006;73:518–522
  118. Grassi W, Tittarelli E, Blasetti P, et al. Finger tendon involvement in rheumatoid arthritis. Evaluation with high-frequency ultrasound. Arthritis and Rheumatism. 1995;38:786–794
  119. Swen WAA, Jacobs JWG, Hubach PCG, et al. Comparison of sonography and magnetic resonance imaging for the diagnosis of partial tears of finger extensor tendons in rheumatoid arthritis. Rheumatology. 2000;39:55–62
  120. Grassi W, Filippucci E, Farina A, et al. Sonographic imaging of tendons. Arthritis and Rheumatism. 2000;43:969–976
  121. Falsetti P, Frediani B, Acciai C, et al. Ultrasonography and magnetic resonance imaging of heel fat pad inflammatory-oedematous lesions in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 2006;35:454–458
  122. Wakefield RJ, O'Connor PJ, Conaghan PG, et al. Finger tendon disease in untreated early rheumatoid arthritis: a comparison of ultrasound and magnetic resonance imaging. Arthritis and Rheumatism. 2007;57:1158–1164
  123. Wakefield RJ, Gibbon WW, Conaghan PG, et al. The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis. Arthritis and Rheumatism. 2000;43:2762–2770
  124. Alarcon GS, Lopez-Ben R, Moreland LW. High-resolution ultrasound for the study of target joints in rheumatoid arthritis. Arthritis and Rheumatism. 2002;46:1969–1970
  125. Hoving JL, Buchbinder R, Hall S, et al. A comparison of magnetic resonance imaging, sonography, and radiography of the hand in patients with early rheumatoid arthritis. The Journal of Rheumatology. 2004;31:663–675
  126. Wakefield RJ, Balint PV, Szkudlarek M, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. The Journal of Rheumatology. 2005;32:2485–2487
  127. Naredo E, Moller I, Moragues C, et al. Inter-observer reliability in musculoskeletal ultrasonography: results from a ‘Teach-the-Teachers’ rheumatologist course. Annals of the Rheumatic Diseases. 2005;65:14–19
  128. Scheel AK, Schmidt WA, Hermann KG, et al. Interobserver reliability of rheumatologists performing musculoskeletal ultrasonography: results from a EULAR ‘Train the trainers’ course. Annals of the Rheumatic Diseases. 2005;64:1043–1049
  129. Szkudlarek M, Petersen J, Ejbjerg BJ, et al. Ultrasonographic and clinical assessments of disease activity during infliximab and methotrexate therapy of RA patients. Annals of the Rheumatic Diseases. 2005;64(Suppl. III):63
  130. Naredo E, Gamero F, Bonilla G, et al. Ultrasonographic assessment of inflammatory activity in rheumatoid arthritis: comparison of extended versus reduced joint evaluation. Clinical and Experimental Rheumatology. 2005;23:881–884
  131. Naredo E, Rodriguez M, Campos C, et al. Validity, reproducibility, and responsiveness of a twelve-joint simplified power Doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis and Rheumatism. 2008;59:515–522
  132. Østergaard M, Szkudlarek M. Ultrasonography – a valid method for assessment of rheumatoid arthritis?. Arthritis and Rheumatism. 2005;52:681–686
  133. Hameed B, Pilcher J, Heron C, et al. The relation between composite ultrasound measures and the DAS28 score, its components and acute phase markers in adult RA. Rheumatology (Oxford, England). 2008;47:476–480
  134. Schueller-Weidekamm C, Krestan C, Schueller G, et al. Power Doppler sonography and pulse-inversion harmonic imaging in evaluation of rheumatoid arthritis synovitis. AJR. American Journal of Roentgenology. 2007;188:504–508
  135. Terslev L, Torp-Pedersen S, Qvistgaard E, et al. Effects of treatment with etanercept (Enbrel, TNRF:Fc) on rheumatoid arthritis evaluated by Doppler ultrasonography. Annals of the Rheumatic Diseases. 2003;62:178–181
  136. Ribbens C, Andre B, Marcelis S, et al. Rheumatoid hand joint synovitis: gray-scale and power Doppler US quantifications following anti-tumor necrosis factor-alpha treatment: pilot study. Radiology. 2003;229:562–569
  137. Taylor PC, Steuer A, Gruber J, et al. Comparison of ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, placebo-controlled study of infliximab therapy in early rheumatoid arthritis. Arthritis and Rheumatism. 2004;50:1107–1116
  138. Filippucci E, Iagnocco A, Salaffi F, et al. Power Doppler sonography monitoring of synovial perfusion at the wrist joints in patients with rheumatoid arthritis treated with adalimumab. Annals of the Rheumatic Diseases. 2006;65:1433–1437
  139. Taylor PC, Steuer A, Gruber J, et al. Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis. Arthritis and Rheumatism. 2006;54:47–53
  140. Boesen M, Boesen L, Jensen KE, et al. Clinical outcome and imaging changes after intraarticular (IA) application of etanercept or methylprednisolone in rheumatoid arthritis: magnetic resonance imaging and ultrasound-Doppler show no effect of IA injections in the wrist after 4 weeks. The Journal of Rheumatology. 2008;35:584–591
  141. Strunk J, Strube K, Muller-Ladner U, et al. Three dimensional power Doppler ultrasonography confirms early reduction of synovial perfusion after intra-articular steroid injection. Annals of the Rheumatic Diseases. 2006;65:411–412
  142. Iagnocco A, Perella C, Naredo E, et al. Etanercept in the treatment of rheumatoid arthritis: clinical follow-up over one year by ultrasonography. Clinical Rheumatology. 2008;27:491–496
  143. Iagnocco A, Filippucci E, Perella C, et al. Clinical and ultrasonographic monitoring of response to adalimumab treatment in rheumatoid arthritis. The Journal of Rheumatology. 2008;35:35–40
  144. Balint PV, Kane D, Wilson H, et al. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Annals of the Rheumatic Diseases. 2002;61:905–910
  145. Genc H, Cakit BD, Tuncbilek I, et al. Ultrasonographic evaluation of tendons and enthesal sites in rheumatoid arthritis: comparison with ankylosing spondylitis and healthy subjects. Clinical Rheumatology. 2005;24:272–277
  146. Scheel AK, Hermann KG, Ohrndorf S, et al. Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. Annals of the Rheumatic Diseases. 2006;65:595–600
  147. Bajaj S, Lopez-Ben R, Oster R, et al. Ultrasound detects rapid progression of erosive disease in early rheumatoid arthritis: a prospective longitudinal study. Skeletal Radiology. 2007;36:123–128
  148. Naredo E, Collado P, Cruz A, et al. Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis and Rheumatism. 2007;57:116–124

PII: S1521-6942(08)00111-3

doi: 10.1016/j.berh.2008.09.014

Best Practice & Research Clinical Rheumatology
Volume 22, Issue 6 , Pages 1019-1044 , December 2008

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