Best Practice & Research Clinical Rheumatology
Volume 23, Issue 4 , Pages 549-561 , August 2009

Challenges of ethnicity in SLE

  • Kanta Kumar, BSc, Dip. RN (Rheumatology Clinical Research Nurse)

      Affiliations

    • Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
    • Rheumatology Department, Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Dudley Road, Birmingham, UK
    • Corresponding Author InformationCorresponding author. Rheumatology Department, Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Dudley Road, Birmingham, B18 7QH, UK. Tel.: +44 121 507 5793; Fax: +44 121 507 5451.
    • ,
  • Sharon Chambers, MD, MRCP (Rheumatology Specialist Registrar)

      Affiliations

    • Department of Medicine, The Centre for Rheumatology, University College London, London, UK
    • ,
  • Caroline Gordon, MD, FRCP (Professor of Rheumatology)

      Affiliations

    • Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
    • Rheumatology Department, Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Dudley Road, Birmingham, UK

References 

  1. Johnson AE, Gordon C, Palmer RG, Bacon PA. The Prevalence and incidence of systemic lupus-erythematosus in Birmingham, England - relationship to ethnicity and Country of Birth. Arthritis Rheum. 1995;38(4):551–558
  2. Hopkinson ND. Systemic lupus erythematosus: epidemiological clues to aetiology. Br J Hosp Med. 1991;45(5):291–293
  3. McCarty DJ, Manzi S, Medsger TA, et al. Incidence of systemic lupus erythematosus. Race and gender differences. Arthritis Rheum. 1995;38(9):1260–1270
  4. Uramoto KM, Michet CJ, Thumboo J, et al. Trends in the incidence and mortality of systemic lupus erythematosus, 1950–1992. Arthritis Rheum. 1999;42(1):46–50
  5. Maskarinec G, Katz AR. Prevalence of systemic lupus erythematosus in Hawaii: is there a difference between ethnic groups?. Hawaii Med J. 1995;54(2):406–409
  6. Hart HH, Grigor RR, Caughey DE. Ethnic difference in the prevalence of systemic lupus erythematosus. Ann Rheum Dis. 1983;42(5):529–532
  7. Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006;15(5):308–318
  8. Anstey NM, Bastian I, Dunckley H, Currie BJ. Systemic lupus erythematosus in Australian aborigines: high prevalence, morbidity and mortality. Aust N Z J Med. 1993;23(6):646–651
  9. Houghton KM, Page J, Cabral DA, et al. Systemic lupus erythematosus in the pediatric North American native population of British Columbia. J Rheumatol. 2006;33(1):161–163
  10. Patel M, Clarke AM, Bruce IN, Symmons DP. The prevalence and incidence of biopsy-proven lupus nephritis in the UK: evidence of an ethnic gradient. Arthritis Rheum. 2006;54(9):2963–2969
  11. Cooper GS, Parks CG, Treadwell EL, et al. Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States. Lupus. 2002;11(3):161–167
  12. Ward MM, Studenski S. Clinical manifestations of systemic lupus erythematosus. Identification of racial and socioeconomic influences. Arch Intern Med. 1990;150(4):849–853
  13. Burling F, Ng J, Thein H, et al. Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort. Lupus. 2007;16(10):830–837
  14. Uribe AG, Alarcon GS. Ethnic disparities in patients with systemic lupus erythematosus. Curr Rheumatol Rep. 2003;5(5):364–369
  15. Samanta A, Feehally J, Roy S, et al. High prevalence of systemic-disease and mortality in Asian subjects with systemic lupus-erythematosus. Ann Rheum Dis. 1991;50(7):490–492
  16. Fernandez M, Alarcon GS, Calvo-Alen J, et al. A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE. Arthritis Rheum. 2007;57(4):576–584
  17. Bertoli AM, Vila LM, Reveille JD, Alarcon GS. Systemic lupus erythaematosus in a multiethnic US cohort (LUMINA) LIII: disease expression and outcome in acute onset lupus. Ann Rheum Dis. 2008;67:500–504
  18. Walsh SJ, Algert C, Gregorio DI, et al. Divergent racial trends in mortality from systemic lupus erythematosus. J Rheumatol. 1995;22(9):1663–1668
  19. Alarcon GS, McGwin G, Bartolucci AA, et al. Systemic lupus erythematosus in three ethnic groups. IX. Differences in damage accrual. Arthritis Rheum. 2001;44(12):2797–2806
  20. Duran S, Apte M, Alarcon GS. Poverty, not ethnicity, accounts for the differential mortality rates among lupus patients of various ethnic groups. J Natl Med Assoc. 2007;99(10):1196–1198
  21. Barr RG, Seliger S, Appel GB, et al. Prognosis in proliferative lupus nephritis: the role of socio-economic status and race/ethnicity. Nephrol Dial Transplant. 2003;18(10):2039–2046
  22. Johnson SR, Urowitz MB, Ibanez D, Gladman DD. Ethnic variation in disease patterns and health outcomes in systemic lupus erythematosus. J Rheumatol. 2006;33(10):1990–1995
  23. Alarcon GS, McGwin G, Sanchez ML, et al. Systemic lupus erythematosus in three ethnic groups. XIV. Poverty, wealth, and their influence on disease activity. Arthritis Rheum. 2004;51(1):73–77
  24. Adler M, Chambers SC, Edwards C, et al. An assessement of renal failure in an SLE cohort with special reference to ethnicity, over a 25 year period. Rheumatology. 2006;45:1144–1147
  25. Kumar K, Daley E, Carruthers DM, et al. Delay in Presentation to primary care physicians is the main reason why patients with rheumatoid arthritis are seen late by rheumatologist. Rheumatology. 2007;46(9):1438–1440
  26. Sheppard J, Kumar K, Buckley CD, et al. 'I just thought it was normal aches and pains; a qualitative study of decision making processes in with early rheumatoid arthritis. Rheumatology. 2008;47(10):1577–1582
  27. Gilley J. Towards rational prescribing. BMJ. 1994;308(6931):731–732
  28. Beardon PH, McGilchrist MM, McKendrick AD, et al. Primary non-compliance with prescribed medication in primary care. BMJ. 1993;307(6908):846–848
  29. Treharne GJ, Lyons AC, Hale ED, et al. ‘Compliance’ is futile but is ‘concordance’ between rheumatology patients and health professionals attainable?. Rheumatology (Oxford). 2006;45(1):1–5
  30. Petri M, Perez-Gutthann S, Longenecker JC, Hochberg M. Morbidity of systemic lupus erythematosus: role of race and socioeconomic status. Am J Med. 1991;91(4):345–353
  31. Bruce IN, Gladman DD, Urowitz MB. Factors associated with refractory renal disease in patients with systemic lupus erythematosus: the role of patient nonadherence. Arthritis Care Res. 2000;13(6):406–408
  32. Rojas-Serrano J, Cardiel MH. Lupus patients in an emergency unit. Causes of consultation, hospitalization and outcome. A cohort study. Lupus. 2000;9(8):601–606
  33. Osterberg L, Terrence B. Adherence to medication. N Engl J Med. 2005;353:487–497
  34. Koehler AM, Maibach HI. Electronic monitoring in medication adherence measurement. Implications for dermatology. Am J Clin Dermatol. 2001;2(1):7–12
  35. Hugen PW, Langebeek N, Burger DM, et al. Assessment of adherence to HIV protease inhibitors: comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring. J Acquir Immune Defic Syndrs. 2002;30(3):324–334
  36. Bangsberg DR, Hecht FM, Clague H, et al. Provider assessment of adherence to HIV antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;26(5):435–442
  37. Koneru S, Shishov M, Ware A, et al. Effectively measuring adherence to medications for systemic lupus erythematosus in a clinical setting. Arthritis Rheum. 2007;57(6):1000–1006
  38. de KE, van der HD, Landewe R, et al. The compliance-questionnaire-rheumatology compared with electronic medication event monitoring: a validation study. J Rheumatol. 2003;30(11):2469–2475
  39. Garcia-Gonzalez A, Richardson M, Garcia Popa-Lisseanu M, et al. Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol. 2008;27(7):883–889
  40. McElhone K, Teh L-S, Walker J, Abbott J. Treatment adherence in systemic lupus erythematosus (SLE). Rheumatology. 2005;44(Suppl.):i141
  41. Koneru S, Kocharla L, Higgins GC, et al. Adherence to medications in systemic lupus erythematosus. J Clin Rheumatol. 2008;14(4):195–201
  42. Garcia Popa-Lisseanu MG, Greisinger A, Richardson M, et al. Determinants of treatment adherence in ethnically diverse, economically disadvantaged patients with rheumatic disease. J Rheumatol. 2005;32(5):913–919
  43. Morgan M. The significance of ethnicity for health promotion: patients' use of anti-hypertensive drugs in inner London. Int J Epidemiol. 1995;24(Suppl. 1):S79–S84
  44. Lip GY, Khan H, Bhatnagar A, et al. Ethnic differences in patient perceptions of heart failure and treatment: the West Birmingham heart failure project. Heart. 2004;90(9):1016–1019
  45. Shenolikar RA, Balkrishnan R, Camacho FT, et al. Race and medication adherence in medicaid enrollees with type-2 diabetes. J Natl Med Assoc. 2006;98(7):1071–1077
  46. Lawton J, Ahmad N, Hallowell N, et al. Perceptions and experiences of taking oral hypoglycaemic agents among people of Pakistani and Indian origin: qualitative study. BMJ. 2005;330(7502):1247
  47. Helliwell PS, Ibranhim G. Ethnic differences in responses to disease modifying drugs. Rheumatology. 2003;42:1197–1201
  48. Connell P, McKevitt C, Wolfe C. Strategies to manage hypertension: a qualitative study with black Caribbean patients. Br J Gen Pract. 2005;55:357–361
  49. Rathwell T, Phillips DR. Health, race & ethnicity. London: Croon Helm; 1986;
  50. Goldberg AI, Cohen G, Rubin AH. Physician assessments of patient compliance with medical treatment. Soc Sci Med. 1998;47(11):1873–1876
  51. Mosley-Williams A, Lumley MA, Gillis M, et al. Barriers to treatment adherence among African American and white women with systemic lupus erythematosus. Arthritis Rheum. 2002;47(6):630–638
  52. Morisky DE, Green LW, Levine DM. Concurrent and predictive-validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67–74
  53. Chambers SA, Raine R, Rahman A, Isenberg D. Ethnicity and adherence to medications in patients with systemic lupus erythematosus (SLE). Arthritis Rheum. 2007;56(9 Suppl.):S731
  54. Chambers SA, Raine R, Rahman A, Isenberg D. Why do patients with systemic lupus erythematosus take or fail to take their prescribed medications? A qualitative study in a UK cohort. Rheumatology (Oxford) 2009;48(3):266--71.
  55. Pyne D, Chaabo K. Adherence to immunosuppressant drugs in patients with connective tissue diseases. Rheumatology (Oxford). 2007;46(12):1859
  56. Chambers S, Raine R, Rahman A, et al. Factors influencing adherence to medications in a group of patients with systemic erythematosus in Jamaica. Lupus. 2008;17:761–769
  57. Thomas VN, Saleem T, Abraham R. Barriers to effective uptake of cancer screening among Black and minority ethnic groups. Int J Palliat Nurs. 2005;11(11):564–571
  58. Kumar K, Gordon C, Toescu V, et al. Beliefs about medicines in patients with RA and SLE: a comparison between patients of South Asian and White British origin. Rheumatology. 2008;47(5):690–697
  59. Phatak HM, Thomas J. Relationships between beliefs about medications and nonadherence to prescribed chronic medications. Ann Pharmacother. 2006;40(10):1737–1742
  60. Horne R, Weinman J. Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res. 1999;47(6):555–567
  61. Williams AM, Lumley MA, Gillis M, et al. Barriers to treatment adherence among African American and White Women with systemic lupus erythematosus. Arthritis Rheum. 2002;47(6):630–638
  62. Moore , Petri MA, Manzi S, et al. The use of alternative medical therapies in patients with systemic lupus erythematosus. Arthritis Rheum. 2000;43(6):1410–1418
  63. Leong KP, Pong LY, Chan SP. Why lupus patients use alternative medicine. Lupus. 2003;12:659–664
  64. Kuo GM, Hawley ST, Weiss LT, et al. Factors associated with herbal use among urban multiethnic primary care patients: a cross-sectional survey. Complement Altern Med. 2004;4(18):
  65. Sutcliffe N, Clarke AE, Gordon C, et al. The association of socio-economic status, race, psychosocial factors and outcome in patients with systemic lupus erythematosus. Rheumatology. 1999;38:1130–1137
  66. Lip GY, Kamath S, Jafri M, et al. Ethnic differences in patient perceptions of atrial fibrillation and anticoagulation therapy: the West Birmingham Atrial Fibrillation Project. Stroke. 2002;33(1):238–242
  67. Kumar K, Deeming A, Gordon C, et al. Experience with a Punjabi, Urdu and Hindi rheumatology telephone helpline. Musculoskeletal Care. 2009;7(3):
  68. Bertoli A, Alarcon G. Epidemiology of systemic lupus erythematosus. In:  Tsokos G,  Gordon C,  Smolen J editor. Systemic lupus erythematosus: a companion to rheumatology. 1st edn.. Philadelphia: Mosby Elsevier; 2007;p. 1–18

PII: S1521-6942(09)00046-1

doi: 10.1016/j.berh.2009.04.005

Best Practice & Research Clinical Rheumatology
Volume 23, Issue 4 , Pages 549-561 , August 2009

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