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Best Practice & Research Clinical Rheumatology
Volume 23, Issue 6
, Pages 741-753
, December 2009
Quantifying the material and structural determinants of bone strength
References
- . Bone health and osteoporosis: a report of the surgeon general. Rockville, MD: U.S. Department of Health and Human Services, Office of the Surgeon General; 2004;
- . Clinical practice. Postmenopausal osteoporosis. N Engl J Med. 2005;353(6):595–603
- Non-compliance: the Achilles' heel of anti-fracture efficacy. Osteoporos Int. 2007;18(6):711–719
- Proceedings of a symposium. Consensus Development Conference on Osteoporosis. October 19–20, 1990, Copenhagen, Denmark. Am J Med. 1991;91(5B):1S–68
- . Biomechanics of age-related fractures. In: Marcus R, Feldman D, Nelson D, Rosen C editor. 3rd edn.. Osteoporosis. vol. I:San Diego, CA: Elsevier Academic Press; 2007;p. 601–616
- Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005;20(7):1185–1194
- Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004;164(10):1108–1112
- Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005;90(5):2787–2793
- Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34(1):195–202
- . How drugs decrease fracture risk: lessons from trials. J Musculoskelet Neuronal Interact. 2002;2(3):198–200
- Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res. 2002;17(1):1–10
- . Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone. 2004;34(4):599–604
- . Relationship between changes in BMD and nonvertebral fracture incidence associated with risedronate: reduction in risk of nonvertebral fracture is not related to change in BMD. J Bone Miner Res. 2005;20(12):2097–2104
- . Bone quality: where do we go from here?. Osteoporos Int. 2003;14(Suppl. 5):118–127
- . Bone quality–the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354(21):2250–2261
- . Quality and performance measures in bone densitometry: part 1: errors and diagnosis. Osteoporos Int. 2006;17(9):1283–1292
- . Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996;312(7041):1254–1259
- . Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: World Health Organization; 1994;
- . New approaches for interpreting projected bone densitometry. J Bone Miner Res. 1992;7:137–145
- . Measuring the structural strength of bones with dual-energy X-ray absorptiometry: principles, technical limitations, and future possibilities. Osteoporos Int. 2003;14(Suppl. 5):81–88
- Structural effects of raloxifene on the proximal femur: results from the multiple outcomes of raloxifene evaluation trial. Osteoporos Int. 2006;17(4):575–586
- Effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double-blind, placebo-controlled clinical trial. J Bone Miner Res. 2005;20(9):1525–1532
- Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone. 2005;36(6):948–958
- DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass. Osteoporos Int. 2009;20(6):911–921
- Hormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the Women's Health Initiative hormone intervention trials. J Bone Miner Res. 2008;23(12):1935–1945
- Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone. 2000;27(5):687–694
- Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone. 2001;29(2):185–191
- Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab. 2003;88(9):4199–4205
- The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover. Bone. 2005;37(1):1–9
- Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab. 2003;88(3):1150–1156
- Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res. 2001;16(6):1108–1119
- Effects of current and discontinued estrogen replacement therapy on hip structural geometry: the study of osteoporotic fractures. J Bone Miner Res. 2001;16(11):2103–2110
- Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study. Bone. 2000;27(1):151–159
- . Cross-sectional geometry, bone strength, and bone mass in the proximal femur in black and white postmenopausal women. J Bone Miner Res. 2000;15(10):1992–1997
- . Does body size account for gender differences in femur bone density and geometry?. J Bone Miner Res. 2001;16(7):1291–1299
- Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study. Osteoporos Int. 2002;13(1):48–54
- Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women. J Am Geriatr Soc. 2005;53(2):183–189
- Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone. 2003;32(5):561–570
- . Structural trends in the aging proximal femur in Japanese postmenopausal women. Bone. 2007;41(1):97–102
- Effects of physical activity on evolution of proximal femur structure in a younger elderly population. Bone. 2007;40(2):506–515
- Sex hormone status may modulate rate of expansion of proximal femur diameter in older women alongside other skeletal regulators. J Clin Endocrinol Metab. 2007;92(1):304–313
- Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study. Bone. 2007;40(3):743–750
- Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study. Calcif Tissue Int. 2007;81(3):162–173
- Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish. Bone. 2008;43(3):607–612
- Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study. Osteoporos Int. 2006;17(2):231–236
- Contribution of hip strength indices to hip fracture risk in elderly men and women. J Bone Miner Res. 2005;20(10):1820–1827
- Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res. 2007;22(11):1781–1790
- Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fractures. J Bone Miner Res. 2008;23(12):1892–1904
- Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004;19(12):1945–1954
- Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006;21(8):1197–1206
- Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone. 2006;39(3):644–651
- Race and ethnic variation in proximal femur structure and BMD among older men. J Bone Miner Res. 2008;23(1):121–130
- The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003;349(13):1207–1215
- The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med. 2003;349(13):1216–1226
- Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med. 2005;165(15):1762–1768
- Hetereogeneity in skeletal response to full-length parathyroid hormone in the treatment of osteoporosis. Osteoporos Int. 2007;18(7):973–979
- Once-monthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis. J Clin Endocrinol Metab. 2009;94(1):171–180
- Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronate. J Clin Endocrinol Metab. 2008;93(10):3785–3793
- A comparison of bone densitometry measurements of the central skeleton in post-menopausal women with and without vertebral fracture. Br J Radiol. 1995;68(811):747–753
- Trabecular texture analysis of CT images in the relationship with spinal fractures. Radiology. 1995;194:55–59
- Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Miner Res. 1997;12:697–711
- . Assessment of vertebral bone mineral density using volumetric quantitative CT. J Comput Assist Tomogr. 1999;23(1):130–137
- A comparison of spinal quantitative computed tomography with dual energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures. Calcif Tissue Int. 2001;68(2):74–82
- Bone density reduction in various measurement sites in men and women with osteoporotic fractures of spine and hip: the European quantitation of osteoporosis study. Calcif Tissue Int. 1999;64(3):191–199
- Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures. Bone. 2002;30(1):247–250
- . Quantitative computed tomography of the lumbar spine, not dual x-ray absorptiometry, is an independent predictor of prevalent vertebral fractures in postmenopausal women with osteopenia receiving long-term glucocorticoid and hormone-replacement therapy. Arthritis Rheum. 2002;46(5):1292–1297
- . The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study. Osteoporos Int. 2005;16(12):1794–1802
- Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*. J Bone Miner Res. 2007;22(12):1862–1868
- Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res. 2008;23(8):1326–1333
- Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res. 2005;20(10):1828–1836
- Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo: results from the EUROFORS study. J Bone Miner Res. 2007;22(9):1426–1433
- . In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005;90(12):6508–6515
- Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006;21(1):124–131
- Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men. J Clin Endocrinol Metab. 2005;91(3):885–891
- . Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007;22(3):425–433
- Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res. 2007;22(9):1442–1448
- High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res. 2008;23(11):1741–1750
- A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008;23(2):205–214
- In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008;23(4):463–474
- Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT. Osteoporos Int. 2009;20(10):1683–1694
- . Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2007;29(10):1096–1105
- Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res. 2008;23(3):392–399
- Seeman E, Delmas PD, Hanley DA, et al. Effects of denosumab and alendronate on skeletal microarchitecture International Bone and Mineral Society Meeting, Sydney. 2009.
- Strontium ranelate has a more positive influence than alendronate on distal tibia cortical and trabecluar bone microstructure in women with postmenopausal osteoporosis. Osteoporos Int. 2009;20:165–166
- . Changes in bone remodeling rate influence the degree of mineralization of bone. Connect Tissue Res. 2002;43(2–3):535–537
- Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996;11(9):1302–1311
- . Quantitative MRI for the assessment of bone structure and function. NMR Biomed. 2006;19(7):731–764
- . Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging. 2007;25(2):390–409
- Imaging of trabecular bone structure in osteoporosis. Eur Radiol. 1999;9(9):1781–1788
- Role of magnetic resonance for assessing structure and function of trabecular bone. Top Magn Reson Imaging. 2002;13(5):335–355
- Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanics. Osteoporos Int. 1996;6(5):376–385
- High-resolution MRI vs multislice spiral CT: which technique depicts the trabecular bone structure best?. Eur Radiol. 2003;13(4):663–671
- Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int. 2005;16(11):1307–1314
- Application of refocused steady-state free-precession methods at 1.5 and 3
T to in vivo high-resolution MRI of trabecular bone: simulations and experiments. J Magn Reson Imaging. 2005;21(6):818–825 - Three-dimensional image registration of MR proximal femur images for the analysis of trabecular bone parameters. Med Phys. 2008;35(10):4630–4639
- Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab. 2003;88(4):1497–1502
- . Quantitative high-resolution magnetic resonance imaging reveals structural implications of renal osteodystrophy on trabecular and cortical bone. J Magn Reson Imaging. 2004;20(1):83–89
- Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging. J Bone Miner Res. 1997;12(1):111–118
- Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. 1998;206(2):347–357
- In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res. 1998;13(7):1175–1182
- Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group. Osteoporos Int. 1999;10(3):231–239
- Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res. 2001;16(8):1520–1531
- . Imaging of trabecular bone structure. Semin Musculoskelet Radiol. 2002;6(3):253–261
- Effect of testosterone replacement on trabecular architecture in hypogonadal men. J Bone Miner Res. 2005;20(10):1785–1791
- Effects of salmon calcitonin on trabecular microarchitecture as determined by magnetic resonance imaging: results from the QUEST study. J Bone Miner Res. 2005;20(9):1548–1561
- Multinuclear solid-state three-dimensional MRI of bone and synthetic calcium phosphates. Proc Natl Acad Sci U S A. 1999;96(4):1574–1578
- Density of organic matrix of native mineralized bone measured by water- and fat-suppressed proton projection MRI. Magn Reson Med. 2003;50(1):59–68
- Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging. Magn Reson Med. 2006;56(5):946–952
- Water- and fat-suppressed proton projection MRI (WASPI) of rat femur bone. Magn Reson Med. 2007;57(3):554–567
- Quantitative bone matrix density measurement by water- and fat-suppressed proton projection MRI (WASPI) with polymer calibration phantoms. Magn Reson Med. 2008;60(6):1433–1443
- . Human imaging of phosphorus in cortical and trabecular bone in vivo. Magn Reson Med. 2004;51(5):888–892
- . Bone quality fills holes in fracture risk. Science. 2005;308(5728):1580
- Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech. 1999;32(10):1013–1020
- . Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone. 2003;33(4):744–750
- Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone. 2002;30(6):842–848
- . High-resolution three-dimensional-pQCT images can be an adequate basis for in-vivo microFE analysis of bone. J Biomech Eng. 2001;123(2):176–183
- . Effect of bone distribution on vertebral strength: assessment with a patient-specific nonlinear finite element analysis. Radiology. 1991;179:669–674
- Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007;22(12):1885–1892
- Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis. J Bone Miner Res. 2007;22(1):149–157
- Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res. 2008;23(12):1974–1982
- Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: results from the EUROFORS study. J Bone Min Res. 2009;24(10):1672–1680
- Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int. 2005;16(6):642–650
- In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical properties of trabecular bone in the radius. Osteoporos Int. 2002;13(1):6–17
- . High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after one year of idoxifene treatment. Clin Biomech (Bristol, Avon). 2002;17(2):81–88
PII: S1521-6942(09)00101-6
doi: 10.1016/j.berh.2009.09.008
© 2009 Elsevier Ltd. All rights reserved.
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Best Practice & Research Clinical Rheumatology
Volume 23, Issue 6
, Pages 741-753
, December 2009
