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Best Practice & Research Clinical Rheumatology
Volume 24, Issue 4
, Pages 553-563
, August 2010
Targeting the B Cell in Rheumatoid Arthritis
References
- . Sustained Improvement in Rheumatoid Arthritis following a Protocol to Designed to Deplete B Lymphocytes. Rheumatology. 2001;40:205–211
- Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B cell Depletion therapy is Mediated by Reduction in Autoantibodies and CD4 + Reactivity. J of Immunology. 2008;180:4994–5003
- The Role of B cell Abnormalities in the Systemic Autoimmune Syndromes of lpr and gld Mice. Semin Immunol. 1994;6:49–54
- T cell activation in rheumatoid arthritis is B cell dependent. J Immunol. 2001;167:4710–4718
- . Do self-perpetuating B lymphocytes drive human autoimmune disease?. Immunology. 1999;97:188–196
- . Therapeutic B Cell Depletion and Regeneration in Rheumatoid Arthritis. Arth and Rheum. 2006;54:2356–2367
- Serologic Changes Following B Lymphocyte depletion therapy for rheumatoid arthritis. Arth and Rheum. 2003;48:2146–2154
- . of Antigen-antibody Complexes by rheumatoid Factor B cells. J Exp Med. 1991;173:487–489
- B Lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med. 1998;187:1009–1018
- Molecular Cloning of the Human B cell CD20 Receptor Predicts a Hydrophobic Protein with Multiple Transmembrane Domains. EMBO J. 1988;7:711–717
- Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000;6:443–446
- Therapeutic Activity of humanized anti-CD20 Monoclonal Antibody and polymorphism in IgG Fc Receptor FcGamma R111a Gene. Blood. 2002;99:754–758
- The Efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a Phase IIB Randomized Trial. Arth and Rheum. 2006;54:1390–1400
- Rituximab Pharmacokinetics in Patients with rheumatoid Arthritis: B cell Levels do not Correlate with Clinical Response. J Clin Pharmacol. 2007;47:1119–1131
- B cell depletion as a novel treatment for systemic lupus erythematosus: a Phase I/II dose-escalation trial of Rituximab. Arthritis Rheum. 2004;50:2580–2589
- Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis. Arthritis Rheum. 2008;58:2993–2999
- Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment. Arthritis Rheum. 2007;56:3909–3918
- Reconstitution of peripheral blood b cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 2006;54:613–620
- . Synovial tissue response to rituximab:mechanism of action and identification of biomarkers of response. Ann Rheum Dis. 2008;67:917–925
- . Anti-CD20 Therapy in patients with rheumatoid arthritis. Arthritis Rheum. 2008;58:1566–1575
- Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004;350:2572–2581
- Continued inhibition of structural damage in rheumatoid arthritis patients treated with rituximab at 2 years: REFLEX study. Arthritis Rheum. 2006;54:1390–1400
- Tak P.P, Cohen S, Emery P et al. Clinical Repsonse Following The First Treatment Course with Rituximab: Effect of Baseline Autoantibody Status. EULAR meeting 2008. FRI0192.
- Silverman G, Schwartzman S, Townsend M et al. Identification of Biomarkers for enhanced Benefit to Rituximab in Rheumatoid Arthritis: Role of Autoantibodies and Inflammatory Markers. Abstract ACR meeting 2009
- Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies. Ann Rheum Dis. 2009;68:216–221
- Emery P, Rigby WF, Combe B, et al. Efficacy and safety of rituximab as first-line biologic therapy in patients with active rheumatoid arthritis: results of a phase III randomized controlled study (SERENE). ACR Abstract 08-A-1290-ACR meeting 2008.
- Rubbert-Roth A, Tak PP, Bombardieri S, et al. Efficacy and safety of various dosing regimens of rituximab in patients with active RA; results of a phase III randomized study (MIRROR). ACR Abstract 08-A-1024-ACR meeting 2008.
- Mease PJ, Cohen S, Gaylis NB, et al. Efficacy, safety, and dose frequency of retreatment with rituximab in RA: results from a randomized controlled trial (SUNRISE). ACR Abstract 08-A-3705-ACR meeting 2008.
- Tak PP, Rigby W, Rubbert A et al. Inhibition Of Joint Damage and Improved Clinical Outcomes With a Combination Of Rituximab And Methotrexate In Patients With Early Active Rheumatoid Arthritis Who Are Naïve To Mtx: A Randomized Active Comparator Placebo Controlled Trial. EULAR meeting 2009:Abstract OP-0022
- Bingham C, Looney R, Deodhar A, et al. Results from a controlled clinical trial (SIERRA) to evaluate primary and recall responses to immunizations in RA patients treated with rituximab. ACR Abstract 08-A-3626-ACR Meeting 2008.
- Genovese M, Breedveld F, Emery P et al. Rate of Serious Infections in Rituximab Treated Patients with Rheumatoid Arthritis Who subsequently Received Other Biologic Therapies. Abstract 0097 EULAR 2009.
- Safety and efficacy of additional courses of rituximab in patients with active rheumatoid arthritis: An open-label extension analysis. Arthritis Rheum. 2007;56:3896–3908
- van Vollenhaven RF, Emery P, Bingham C.O. Long-Term Safety of Rituximab: Follow-up of the RA Clinical Trials and Re-Treatment Population. EULAR meeting 2009 meeting.OP-0026.
- . Important Drug Warning New Safety Information. Avaliable at: http://www.fda.gov/medwatch/safety/2008/rituxan_DHCP_Final%2094411700.pdf2008;Accessed March 2, 2009
- Progressive Multifocal Leukoencephalopathy after Rituximab Therapy in HIV-negative Patients: a Report of 57 Cases from the Research on Adverse Drug Events and Reports Project. Blood. 2009;113:4834–4840
- Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study. Arthritis Rheum. 2008;58:2652–2661
- Burge D;Chopiak V,Dvoretskiy L, et al. TRU-015 Improves Rheumatoid Arthritis Disease Activity in a Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 2 Dose Ranging Trial. Abstract. ACR meeting 2007.
- Stromatt S, Chopiak V, Dvoretskiy L et al. Sustained Safety and Efficacy of TRU-015 with Continued Retreatment of Rheumatoid Arthritis Subjects Following a Phase 2B Study. Abstract ACR meeting 2009.
- Østergaard M, Baslund B, Rigby W et al. Ofatumumab (HUMAX-CD20), A Fully HumanCD20 MONOCLONAL Antibody, In the Treatment of Rheumatoid Arthritis. Early results from an Ongoing, Double Blind, Randomized, Placebo Controlled Clinical Trial. EULAR meeting 2007:OP0232
- An essential role of BAFF in the normal development of b cells through a BCMA –Independent Pathway. Science. 2002;293:2111–2114
- . Severe B cell Hyperplasia and Autoimmune disease in TALL-1 Transgenic Mice. Proc Natl Acad Sci USA. 2000;(7):3370–3375
- nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept. Immunity. 2001;105:200–210
- Elevated Serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arth and Rheum. 2001;44:1313–1319
- . Increase of B Cell Activating Factor of the TNF Fasmily(BAFF) after Rituximab Treatment: insights into a new regulating system of BAFF production. Ann Rheum Dis. 2007;66:700–702
- Belimumab, a fully human monoclonal antibody to B-lymphocyte stimulator, combined with standard of care therapy reduces the signs and symptoms of rheumatoid arthritis in a heterogeneous population. Arth and Rheum. 2005;S710;abstract 1920
- Differential Responsiveness to Belimumab in combination with Standard of Care therapy in RF+, TNF inhibitor and methotrexate partial responder subgroups with moderate-severe rheumatoid arthritis. abstract Arth and Rheum. 1989;S738
- . Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active sle: efficacy and safety results from the phase 3 BLISS-52 Study. Arth and Rheumatism. 2009;60(10):Supplement(PP.S1-S830)
- Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase 1b, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study. Arth & Rheumatism. January 2008;58(Issue 1):61–72
PII: S1521-6942(09)00142-9
doi: 10.1016/j.berh.2009.11.006
© 2009 Elsevier Ltd. All rights reserved.
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Best Practice & Research Clinical Rheumatology
Volume 24, Issue 4
, Pages 553-563
, August 2010
