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Editorial Board/Aims and Scope
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iii
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Preface
Diseases of the musculoskeletal system, as a group, are among those that affect the largest segments of the population and carry the highest cost to society; at the same time, the individual suffers f...
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Dick Heinegård,
Josef S. Smolen
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749-750
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Emerging Frontiers in cartilage and chondrocyte biology
Articular cartilage is a uniquely ordered tissue that is designed to resist compression and redistribute load, but is poorly equipped for self-repair. The chondrocyte is the only resident cell type, r...
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Amanda J. Fosang,
Frank Beier
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751-766
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The synovium as a privileged site in rheumatoid arthritis: Cadherin-11 as a dominant player in synovial pathology
Rheumatoid arthritis is a systemic disease in which an autoimmune response translates primarily into joint inflammation with attendant joint destruction. While evidence implicates both the adaptive an...
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Hans P. Kiener,
Thomas Karonitsch
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767-777
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Joint appendages – the structures which have historically been overlooked in arthritis research and therapy development
Rheumatologists have largely conceptualised joint disease in inflammatory and degenerative arthritis in terms of bone, cartilage and the synovial lining, but have tended to overlook other integral com...
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Zoe Ash,
Dennis McGonagle
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779-784
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Adaptive immunity in rheumatic diseases – Bystander or pathogenic player?
Rheumatic diseases comprise a wide spectrum of different conditions. Some are caused by disturbances of the adaptive immune system, while defects in innate immune responses have been identified for ot...
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Hans Ulrich Scherer,
Gerd-Rüdiger Burmester
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785-800
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Osteoarthritis
The pathogenesis of osteoarthritis (OA) appears to be the result of a complex interplay between mechanical, cellular and biochemical forces. Obesity is the strongest risk factor for disease onset in t...
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David J. Hunter
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801-814
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Biomechanical factors in osteoarthritis
Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint loading – associated to obesity, malalignment, trauma or joint instability – is a critical risk factor ...
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Farshid Guilak
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815-823
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Spondyloarthritides
The most important clinical features of the spondyloarthritides (SpA) are not only inflammatory back pain (IBP) but also peripheral (enthesitis) and extra-articular symptoms. For clinical purposes, tw...
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Xenofon Baraliakos,
Juergen Braun
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825-842
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Emerging targeted therapies in scleroderma lung and skin fibrosis
Systemic sclerosis (SSc) is a multisystemic fibrotic disorder that affects the skin and internal organs. Despite an improved outcome probably reflecting a better management of disease complications, m...
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Britta Maurer,
Oliver Distler
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843-858
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Molecular serum and urine marker repertoire supporting clinical research on joint diseases
The need for improved analytical techniques in the study of slow, degenerative diseases such as rheumatoid arthritis and osteoarthritis has driven major efforts aimed at identifying biochemical marker...
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Per Qvist,
Anne-Christine Bay-Jensen,
Claus Christiansen,
Bodil Cecilie Sondergaard,
Morten A. Karsdal
et al.
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859-872
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Immune modulation of rheumatoid arthritis
The approval – several years ago – of the first tumour necrosis factor-α (TNF-α) inhibitor for the management of rheumatoid arthritis launched a new era in the therapeutics of rheumatology. Since then...
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Dimitrios A. Pappas,
Laura Geraldino-Pardilla,
Joan M. Bathon
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873-889
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Glucocorticoids
Glucocorticoids remain part of the treatment strategy in many rheumatic diseases, because of their anti-inflammatory and immunosuppressive actions. Unfortunately, their clinically desired effects are ...
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Cornelia M. Spies,
Cindy Strehl,
Marlies C. van der Goes,
Johannes W.J. Bijlsma,
Frank Buttgereit
et al.
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891-900
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Index
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I
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